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Neuron 22, 693-705. Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells. 1999

Lo, L., Morin, X., Brunet, J.-F., Anderson, D.J.

Notes: The Glial-Derived Neurotrophic Factor (GDNF) was used to treat Phox2a-infected neural crest cells and induced tyrosine hydroxylase expression. (0740)

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Blood 89, 2925-2937. Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. 1997

Gattei, V., Celetti, A., Cerrato, A., Degan, M., De Iuliis, A., Rossi, F.M., Chiappetta, G., Consales, C., Improta, S., Zagonel, V., Aldinucci, D., Agosti, V., Santoro, M., Vecchio, G., Pinto, A. and Grieco, M.

Notes: Acute myeloid leukemia cells expressing RET were assayed for clonogenic growth of blast cells by GDNF with or without treatment with a phosphoinositol-specific phospholipase C. The GDNFR-alpha is phosphoinositol-linked protein. Cells were also treated with GDNF, reacted with the anti-GDNF antibody and reacted with the FITC-conjugated Anti-chicken IgY. The cells were analyzed by flow cytometry in the presence or absence of the phospholipase C. (1573)

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Proc. Natl. Acad. Sci. USA 94, 6238-6243.. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. 1997

Sanicola, M., Hession, C., Worley, D., Carmillo, P., Ehrenfels, C., Walus, L. , Robinson, S., Jaworski, G., Wei, H., Tizard, R., Whitty, A., Pepinsky, R.B. and Cate, R.L.

Notes: GDNF was used in the culture of NB41A3 neuroblastoma cells to assess the phosphorylation of the tyrosine kinase receptor RET. Also, GDNF was immobilized on microtiter plates and reacted with recombinant RET proteins to demonstrate an interaction. (1594)

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J. Neurosci. 17, 5891-5899. Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro. 1997

Miao, N., Wang, M., Ott, J.A., D'Alessandro, J.S., Woolf, T.M., Bumcrot, D.A., Mahanthappa, N.K., Pang, K.

Notes: Both Recombinant Human Brain-Derived Neurotrophic Factor (BDNF) and Glial Cell-Derived Neurotrophic Factor (GDNF) were assayed for protection of midbrain cultures from the neurotoxin, MPP+. (0688)

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Neuron 17, 595-606. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. 1996

Gross, R.E., Mehler, M.F., Mabie, P.C., Zang, Z., Santschi, L. and Kessler, J.A.

Notes: GDNF was used for various assays of neuronal maturation and quantitative analysis of neuronal and oligodendroglial lineage suppression. All studies were in comparison to bone morphogenetic proteins. (1575)

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