J. Biol. Chem.
Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein.
Yoneda, T., Imaizumi, K., Maeda, M., Yui, D., Manabe, T., Katayama, T., Sato, N., Gomi, F., Morihara, T., Mori, Y., Miyoshi, K., Hitomi, J., Ugawa, S., Yamada, S., Okabe, M., and Tohyama, M.
Notes: The signaling mechanism of Bcl10, an apoptosis-associated gene mutated in mucosa-associated lymphoid tissue lymphomas, was examined. Activation of the JNK signaling pathway in response to overexpression of Bcl10 in 293 cells was monitored by immunoprecipitation with an anti-JNK1 antibody followed by Western blotting with the Anti-ACTIVE® JNKpAb. Immunohistochemical staining of transgenic mice expressing Bcl10 was also performed with the Anti-ACTIVE® JNK pAb. Mouse thymus was fixed in 4% paraformaldehyde, dehydrated, embedded in paraffin, and sectioned (5 µm thick) prior to immunostaining. (2384)
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