We believe this site might serve you best:

United States

United States

Language: English

Promega's Cookie Policy

Our website uses functional cookies that do not collect any personal information or track your browsing activity. When you select your country, you agree that we can place these functional cookies on your device.

Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

Development of a Murine FcgRIV-Specific Antibody-Dependent Cell-mediated Cytotoxicity Reporter Assay Poster

SEARCH POSTERS

Abstract

Teresa Surowy, Aileen Paguio and Frank Fan 
R&D, Promega Corporation, 2800 Woods Hollow Road, Madison WI 53711, USA.

We describe here our development of a bioluminescent murine FcgRIV-specific ADCC reporter assay. ADCC pathway activation by target cell-bound antibodies is achieved via FcgRIV-mediated NFAT activation and consequent induction of reporter luciferase activity in dual engineered Jurkat effector cells. We have further developed the assay with thaw-and-use effector cells for immediate use, reducing assay variability and providing convenience.

Document Icon Download the poster PDF (477kb)

  • Part# PS224
  • Printed in USA.