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A Novel MOA-Based Bioluminescent Bioassay for Quantitative Measurement of anti-VEGF Antibody Potency and Stability

Part # PS319

Abstract

Jennifer Wilkinson, Matt Robers, Frank Fan and Mei Cong
Promega Corporation, 2800 Woods Hollow Rd, Madison, WI 53711


We have developed a bioluminescent reporter-based bioassay that measures VEGF stimulation/inhibition of KDR (VEGFR2). This assay overcomes many of the limitations of the current endothelial cell proliferation assays, and can be used for the discovery and development of novel biologic therapies aimed at either inducing or inhibiting the VEGF response.

Printed in USA.