A Flexible Workflow for Automated Bioluminescent Kinase Selectivity Profiling Poster
Part # PS244
Matt Butzler1, Tracy Worzella1, Jacquelyn Hennek1, Seth Hanson2, Karen Kleman2, Said Goueli1, Hicham Zegzouti1, Mark Bratz1 and Cristopher Cowan1
1Promega Corporation, 2800 Woods Hollow Rd, Madison WI, 53711, USA; 2Gilson Inc., Middleton WI, USA
Kinase profiling is a necessary process to confirm inhibitor selectivity and assess off-target activity. The arduous task of optimizing kinase reactions and maintaining a library of enzymes often results in the outsourcing of kinase profiling activities. We aim to show how ready-to-use Kinase Selectivity Profiling Systems (KSPS) combined with easy-to-use instrumentation and automated data analysis supports a streamlined workflow to enable quick and efficient in-house kinase profiling.
Printed in USA.