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CYP3A4 P450-Glo™ Assays with Luciferin-IPA: The Most Sensitive and Selective Bioluminescent CYP3A4 Assay

James J. Cali, Mary Sobol, Dongping Ma, H. Testsuo Uyeda, Poncho Meisenheimer
Promega Corporation and Promega Biosciences
Publication Date: 2009

Abstract

Here we introduce the newest bioluminescent substrate for cytochrome 3A4, Luciferin-IPA. This new generation substrate is a highly sensitive and selective probe for detecting CYP3A4 activity. The increased sensitivity allows the research to use less CYP3A4 enzyme. The substrate can be used to detect CYP3A4 gene induction and can be multiplexed with a cell viability assay.

Cell Notes 23, 17–19.

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How to Cite This Article

Scientific Style and Format, 7th edition, 2006

Cali, J. J., Sobol, M., Ma, D., Uyeda, H. T. and Meisenheimer, P. CYP3A4 P450-Glo® Assays with Luciferin-IPA: The Most Sensitive and Selective Bioluminescent CYP3A4 Assay. [Internet] 2009. [cited: year, month, date]. Available from: https://www.promega.com/resources/pubhub/cellnotes/cyp3a4-p450-glo-assays-with-luciferin-ipa-the-most-sensitive-and-selective-bioluminescent-cyp3a4/

American Medical Association, Manual of Style, 10th edition, 2007

Cali, J. J., Sobol, M., Ma, D., Uyeda, H. T. and Meisenheimer, P. CYP3A4 P450-Glo® Assays with Luciferin-IPA: The Most Sensitive and Selective Bioluminescent CYP3A4 Assay. Promega Corporation Web site. https://www.promega.com/resources/pubhub/cellnotes/cyp3a4-p450-glo-assays-with-luciferin-ipa-the-most-sensitive-and-selective-bioluminescent-cyp3a4/ Updated 2009. Accessed Month Day, Year.