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Measuring Luminescence Using the Caspase-Glo® 1 Inflammasome Assay with the GloMax® Discover System

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Abstract

The Caspase-Glo® 1 Inflammasome Assay used in combination with the GloMax® Discover System provides a convenient, rapid and sensitive procedure for measuring caspase-1 activity in cells. This plate-based bioluminescent assay enables high throughput screening of inflammasome modulators. This Application Note describes the protocol for measuring luminescence using the GloMax® Discover System with the Caspase-Glo® 1 Inflammasome Assay. In addition, a protocol for multiplexing the Caspase-Glo® 1 Inflammasome Assay and the CellTox™ Green Cytotoxicity is included to monitor caspase-1 activity and pyroptosis.

Application Note #AN294

Promega Corporation Publication Date: May 2016

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How to Cite This Article

  Measuring Luminescence Using the Caspase-Glo® 1 Inflammasome Assay with the GloMax® Discover System. [Internet] May 2016. [cited: year, month, date]. Available from: http://www.promega.com/resources/pubhub/applications-notes/measuring-luminescence-using-the-caspase-glo-1-inflammasome-assay-with-the-glomax-discover-system/

  Measuring Luminescence Using the Caspase-Glo® 1 Inflammasome Assay with the GloMax® Discover System. Promega Corporation Web site. http://www.promega.com/resources/pubhub/applications-notes/measuring-luminescence-using-the-caspase-glo-1-inflammasome-assay-with-the-glomax-discover-system/ Updated May 2016. Accessed Month Day, Year.