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SLAS2019 International Conference & Exhibition

Where Discovery Meets Technology

  • Walter E. Washington Convention Center | Washington, DC.
  •  Saturday, February 2, 2019 – Wednesday, February 6, 2019

Bring your drug screening questions to Booth #1113.
Daily drawings for glass beaker mugs.
Promega Beaker Mug

WORKSHOPS AND SHORT COURSES

Terry Riss
Dr. Terry Riss, Promega Corporation, will be one of the presenters
in a group-led instruction for the following events.
Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
Saturday, February 2, 2019 — 8:00 a.m. - 5:00 p.m. (local time)
Treating Cells as Reagents to Design Reproducible Screening Assays
Description
3D Cell-Based Assays for Drug De-Risking
Saturday, February 2, 2019 — 8:00 a.m. - 5:00 p.m. (local time)
Validating Cell Health Assays Applied to 3D Cultures
Description
Establishing Cell-Based Assays for Screening
Sunday, February 3, 2019 — 8:00 a.m. - 5:00 p.m. (local time)
Cell Viability, Cytotoxicity, Apoptosis and Multiplexing Cell-Based Assays
Description

SCIENTIFIC POSTERS

A Homogeneous Bioluminescent Immunoassay Approach to Interrogate Cellular Signaling Pathways Activation and Deactivation
and
NanoBiT® Homogeneous Immunoassay: A Simple, Sensitive, and Rapid Method for Analyte Detection using Luminescent Signal
Presented by: Hicham Zegzouti, Sr Research Scientist, Promega Corporation

Quantitative Live-Cell Characterization of PROTAC-Induced Degradation and Mechanism of Action
and
Evaluating a No-Wash Rapid FcRn Immunoassay to Guide Development of Antibody Therapeutics
Presented by:  Steve Edenson, Strategic Collaboration Manager, Promega Corporation

High-Throughput, Transfection-Grade Plasmid Purification without Centrifugation using Paramagnetic Particles
Presented by:  Chris D'Jamoos, Strategic Collaboration Manager, Promega Corporation

A Homogeneous Bioluminescence Cell-Specific Cytotoxicity Assay for Surveying Cellular Sub-Populations in Mixed Cultures
Presented by: Richard Somberg, Director--Pharma/Biotech Market Segment, Promega Corporation

Bioluminescent Platform for Cellular Energy Metabolism Studies
Presented by:  Gediminas Vidugiris, Sr Automation Scientist,  Promega Corporation

Application of BRET Technology to Quantitatively Determine Kinase Inhibitor Potency in Live Cells
Presented by: Jianghong Wu, Reaction Biology Corporation

Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
Saturday, February 2, 2019 — 8:00 a.m. - 5:00 p.m. (local time)
Treating Cells as Reagents to Design Reproducible Screening Assays
This full-day workshop will cover a broad range of critical concepts underlying assay development for high throughput screening (HTS) and lead discovery projects. Many of the methodologies successfully implemented in such projects have been "tribal knowledge" within the pharmaceutical industry and not readily found in a classroom or the literature. This "tribal knowledge" has been developed for decades into detailed chapters within the AGM to facilitate reproducible assays that can identify the most promising compounds for development of molecular probes or clinical candidates for drug discovery and development. An increasing number of researchers are actively developing well validated assays for drug discovery that include phenotypic and biochemical assays for lead optimization. This workshop is designed to disseminate critical information about the implementation of robust assay methods and intended to benefit the entire drug discovery community. Many of the workshop instructors have 20-30 years of experience in the field of drug discovery.
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3D Cell-Based Assays for Drug De-Risking
Saturday, February 2, 2019 — 8:00 a.m. - 5:00 p.m. (local time)
Validating Cell Health Assays Applied to 3D Cultures
Cell-based in vitro assays are used throughout the drug discovery and development chain, allowing for high-throughput efficacy but also mechanistic-based toxicity testing. A big challenge, however, is the translation of in vitro assays toward the in vivo outcome. Physiological relevance is a key parameter to improve the predictive power of cell-based assays. The better we can reflect tissue architecture, composition and function, the more predictive an in vitro assay will become. The 3D course covers advances in 3D cell culture technologies, assays and their use in drug discovery and development.
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Establishing Cell-Based Assays for Screening
Sunday, February 3, 2019 — 8:00 a.m. - 5:00 p.m. (local time)
Cell Viability, Cytotoxicity, Apoptosis and Multiplexing Cell-Based Assays
This course will describe developing standard procedures for handling cultured cells to set up cell-based assays, including: 1) techniques for measuring cell health and the pathways leading to cytotoxicity; 2) validation of in vitro assays applied to 3D model systems; 3) cell line authentication as a component of assay reproducibility; 4) developing siRNA screening assays; 5) using CRISPR technology as a validation step; and 6) an overview of various GPCR screening methods.
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