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Drug Discovery Chemistry (DDC) 2020 Resources

Information and resources about kinase biology, protein degradation and more.



Welcome to our resource page for Drug Discovery Chemistry (DDC) 2020. Because we won’t be able to meet you in person, explore this page to discover how we can support your research with our products and technologies.

Visit the DDC 2020 Virtual Event

 

wells-carrow-ddc

Comprehensive Evaluation of CDK Inhibitor Landscape in Cells

Presented by Carrow Wells, Research Associate, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill

Although CDK inhibitors have proven to be therapeutically important, many CDK inhibitors lack family-wide profiling. To address this gap, we evaluated known CDK inhibitors against the full panel of cellular CDK assays. Utilizing the NanoBRET™ assay platform, we identified selective and potent CDK inhibitors, as well as broadly active compounds that can aid in the design of new CDK inhibitors and our ability to match a kinase to a phenotype.

Read the paper: Wells, C.I. et al. (2020) Nature Comm. 11, 2743.

cdk inhibtors target engagement

Scientific Posters

kara machleidt NanoBRET in Live Cells as a Method to Assess E3 Ligase and Target Protein Occupancy for PROTACs

Presented by Kara Machleidt, Global Marketing Manager

Download PDF

Steve-Edenson Real-Time Monitoring of PROTAC and Molecular Glue Targeted Degradation in Living Cells

Presented by Steve Edenson, Strategic Collaborations Manager

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krsitin huwiler Cellular Kinase Assays that Deliver Quantitative Compound Affinity, Occupancy, and Selectivity in Live Cells Using NanoBRET

Presented by Kristin Huwiler, Sr. Product Manager

Download PDF

brian hwang A Simple Homogeneous Bioluminescent Immunoassay to Interrogate Cellular Signaling Pathway Regulation

Presented by Brian Hwang, Sr. Research Scientist

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Protein Degradation

Study protein degradation in live cells from compound cell permeability and E3 ligase engagement to target degradation. Learn about the comprehensive selection of CRISPR-edited cell line pools and clones to facilitate studying popular protein degradation targets that Promega has to offer.

protein degradation crispr knock-in

Kinase Biology

Promega offers biochemical assays for inhibitor screening, kinase-ligand binding assays in live cells and custom kinase assay services. Our bioluminescent assays are available to query the ability of compounds to bind or inhibit kinases in biochemical and cellular formats.

kinase biology

Immunoassays

Try the Lumit™ Immunoassays, a simple and fast alternative to conventional immunoassay methods. These assays are sensitive, have broad dynamic range and can be completed in 30 minutes. They are available as catalog items, early-access material or through our custom order department.

lumit immunoassays

Cell Health

Using high-throughput assays from Promega, you can perform comparative analysis by multiplexing assays with other measures of cell health, such as apoptosis and autophagy. Check out our complete offering of cell health screening assays.

cell health

Would you like more information about our products for drug discovery?

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