Drug Discovery Chemistry (DDC) 2020 Resources
Welcome to our resource page for Drug Discovery Chemistry (DDC) 2020. Because we won’t be able to meet you in person, explore this page to discover how we can support your research with our products and technologies.
Comprehensive Evaluation of CDK Inhibitor Landscape in Cells
Presented by Carrow Wells, Research Associate, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
Although CDK inhibitors have proven to be therapeutically important, many CDK inhibitors lack family-wide profiling. To address this gap, we evaluated known CDK inhibitors against the full panel of cellular CDK assays. Utilizing the NanoBRET™ assay platform, we identified selective and potent CDK inhibitors, as well as broadly active compounds that can aid in the design of new CDK inhibitors and our ability to match a kinase to a phenotype.
Read the paper: Wells, C.I. et al. (2020) Nature Comm. 11, 2743.
Presented by Kara Machleidt, Global Marketing Manager
Presented by Steve Edenson, Strategic Collaborations Manager
Presented by Kristin Huwiler, Sr. Product Manager
Presented by Brian Hwang, Sr. Research Scientist
Study protein degradation in live cells from compound cell permeability and E3 ligase engagement to target degradation. Learn about the comprehensive selection of CRISPR-edited cell line pools and clones to facilitate studying popular protein degradation targets that Promega has to offer.
Promega offers biochemical assays for inhibitor screening, kinase-ligand binding assays in live cells and custom kinase assay services. Our bioluminescent assays are available to query the ability of compounds to bind or inhibit kinases in biochemical and cellular formats.
Try the Lumit™ Immunoassays, a simple and fast alternative to conventional immunoassay methods. These assays are sensitive, have broad dynamic range and can be completed in 30 minutes. They are available as catalog items, early-access material or through our custom order department.
Using high-throughput assays from Promega, you can perform comparative analysis by multiplexing assays with other measures of cell health, such as apoptosis and autophagy. Check out our complete offering of cell health screening assays.