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Proteome-Targeted Drug Discovery Resources

Welcome to our resource page for proteome-targeted drug discovery. Discover how we can support your research with the latest products and technologies to "drug the undruggable".

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Design of Chemical Probes for Target Discovery and Engagement

  • A photoreactive cleavable chloroalkane capture tag that can be attached to bioactive compounds
  • Assess binding affinity and kinetics of target engagement via bioluminescence resonance energy transfer (BRET)
  • Case studies for identification and characterization of physiologically relevant targets for bioactive compounds

Presented by Rachel Ohana, PhD
Sr. Research Scientist, Promega Corporation

Tuesday, November 17
9:40am EST

Register for Virtual Event

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Profiling CDK Family Mechanisms of Degradation

Exploring the correlation of real-time kinetic degradation profiles to ternary complex formation and ubiquitination.

Presented by Kristin Riching, PhD 
Sr. Scientist, Promega Corporation

Scientific Posters

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Real-Time Monitoring of PROTAC and Molecular Glue Targeted Degradation in Living Cells

Kristin Riching, Sr. Scientist

Download Poster

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Targeted Degradation of Endogenously Tagged Proteins for Phenotypic Studies Using HaloPROTAC3 and HaloTag® Technologies

Chris Heid, Sr. Global Commercialization Marketing Manager

Download Poster
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NanoBRET™ in Live Cells as a Method to Assess E3 Ligase and Target Protein Occupancy for PROTACs

Matt Robers, Sr. Research Scientist

Download Poster
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Chemical Proteomic Strategy Utilizing a Photoreactive Chloroalkane Capture Tag for Target Discovery

Rachel Ohana, Sr. Research Scientist

Download Poster

Learn about our mass-spec grade reagents for proteomics analysis!

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Protein Degradation

Study protein degradation in live cells from compound cell permeability and E3 ligase engagement to target degradation. Learn about the comprehensive selection of CRISPR-edited cell line pools and clones to facilitate studying popular protein degradation targets that Promega has to offer.

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CRISPR/Cas9-Knock-in Tagging

CRISPR/Cas9 knock-in tagging offers a convenient method to study endogenous biology, without the drawbacks of overexpression methods. Promega offers a comprehensive selection of CRISPR-edited cell line pools and clones for popular drug targets and cell backgrounds.

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Target Engagement

Promega offers NanoBRET™ Target Engagement Assays which use an energy transfer technique called bioluminescence resonance energy transfer (BRET) to measure molecular proximity. With these assays you are not limited by protein class or cellular background.

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Immunoassays

Try the Lumit™ Immunoassays, a simple and fast alternative to conventional immunoassay methods. These assays are sensitive, have broad dynamic range and can be completed in 30 minutes. They are available as catalog items, early-access material or through our custom order department.

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Protein Interactions

We offer a number of products for high-throughput analysis of protein interactions, including pull-down assays, bioluminescence resonance energy transfer (BRET)-based assays and complementation reporter-based systems.

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