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Protein Degradation Event Resources

Discover how we can support your protein degradation research with our products and technologies.

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Cellular Mechanistic Profiling of Degradation Compounds

  • Several case studies to understand PROTAC mechanisms of action in different systems
  • Correlation of real-time kinetic degradation profiles to ternary complex formation and ubiquitination
  • Cell-based assay strategies for rank ordering compound potency and efficacy

Presented by Danette Daniels, Ph.D.
Sr Research Scientist, Promega Corporation

Wednesday, October 14
10:00—10:30am EDT

Visit the Virtual Event

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Profiling CDK Family Mechanisms of Degradation

Exploring the correlation of real-time kinetic degradation profiles to ternary complex formation and ubiquitination.

Presented by Kristin Riching, Ph.D.
Sr Scientist, Promega Corporation

Scientific Posters

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Real-time Monitoring of PROTAC and Molecular Glue Targeted Degradation in Living Cells

Kristin Riching, Sr Scientist

Download Poster

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Targeted Degradation of Endogenously Tagged Proteins for Phenotypic Studies Using HaloPROTAC3 and HaloTag® Technologies

Chris Heid, Sr Global Commercialization Marketing Manager

Download Poster
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NanoBRET™ in Live Cells as a Method to Assess E3 Ligase and Target Protein Occupancy for PROTACs

Matt Robers, Sr Research Scientist

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Learn about the newest tools to monitor protein degradation dynamics in living cells!

Download PDF

Protein Degradation

Study protein degradation in live cells from compound cell permeability and E3 ligase engagement to target degradation. Learn about the comprehensive selection of CRISPR-edited cell line pools and clones to facilitate studying popular protein degradation targets that Promega has to offer.

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CRISPR/Cas9-Knock-in Tagging

CRISPR/Cas9 knock-in tagging offers a convenient method to study endogenous biology, without the drawbacks of overexpression methods. Promega offers a comprehensive selection of CRISPR-edited cell line pools and clones for popular drug targets and cell backgrounds.

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Target Engagement

Promega offers NanoBRET™ Target Engagement Assays which use an energy transfer technique called bioluminescence resonance energy transfer (BRET) to measure molecular proximity. With these assays you are not limited by protein class or cellular background.

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Immunoassays

Try the Lumit™ Immunoassays, a simple and fast alternative to conventional immunoassay methods. These assays are sensitive, have broad dynamic range and can be completed in 30 minutes. They are available as catalog items, early-access material or through our custom order department.

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Cell Health

Using high-throughput assays from Promega, you can perform comparative analysis by multiplexing assays with other measures of cell health, such as apoptosis and autophagy. Check out our complete offering of cell health screening assays.

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