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American Association for Cancer Research (AACR) 2021 Resources

Check out our many new products, technologies and instrumentation to advance your cancer research.

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New Technology

Fast, No-Wash Lumit™ Immunoassays

Quantify proteins or small molecules without tedious wash steps! Our homogenous Lumit™ Immunoassays are sensitive, have broad dynamic range and can be completed in 70 minutes or less. They provide a simple and fast alternative to conventional immunoassays.

Explore our Lumit™ Immunoassays for cytokine detection, kinase pathway analysis and FcRn binding. Or contact our custom assay team to develop your own Lumit™ application!

Learn how Lumit™ technology can help you get results faster in this free webinar.

Register for Webinar

New Products

What are you interested in? Explore new products in these fields:

Kinase Biology and RAS Signaling

Bioluminescent assays can help determine the ability of compounds to bind or inhibit kinases in biochemical and cellular formats, and are amenable to high-throughput or selectivity profiling. Our new NanoBRET Target Engagement Assays enable you to quantify live-cell target engagement at all described drug binding sites within the RAS-RAF-MEK-ERK pathway, including RAS switch I/II and II pockets. Email us to learn more about these assays.

View this 26-minute presentation describing the use of NanoBRET to quantify live-cell target engagement at RAS and downstream effectors.


Immunogenic Cell Death

It’s now possible to measure two orthogonal markers of immunogenic cell death:

1. HMGB1 release with the homogeneous no-wash Lumit™ HMGB1 ImmunoassayEmail us to learn more about this assay.

2. Kinetic release of extracellular ATP with our new RealTime-Glo™ Extracellular ATP Assay. View video to see how easy it can be to measure extracellular ATP in real-time.


Inflammasome Activation

Want to assess inflammasome activation and inhibition with live cells? Learn about our new homogeneous, no-wash Lumit™ IL-1B Immunoassay, caspase-1 activation assay and live-cell NLRP3 Target Engagement Assay. Email us to learn more about this assay.

3D Culture

Get more physiologically relevant data out of your 3D culture samples with optimized assays for viability, cytotoxicity, apoptosis, and energy metabolism. The new Caspase-Glo® 3/7 3D Assay measures caspase-3 and-7 activities in apoptotic 3D cultures using a simple add-mix-measure protocol.


Bioassays for Biologics

Our functional bioassays can interrogate immune checkpoint modulation, T cell retargeting, cytokine and growth factor signaling, tumor antigen-specific cell killing, and Fc effector activity.

The new PBMC ADCC Assay provides a simple, add-mix-read format with ADCC-qualified human PBMCs, a choice of target cells expressing HiBiT fusion protein and corresponding PBMC ADCC Bioassay Kit. Learn how the assay works in this video.


Circulating Cell-Free DNA (ccfDNA)

The quantity and sequences of ccfDNA molecules found in plasma can indicate the presence of a tumor and offer valuable insights into its characteristics. You can automate ccfDNA extraction from plasma with the new Maxwell® RSC ccfDNA Plasma Kit or high-throughput Maxwell® HT ccfDNA Kit.

Register for the 3-Part ccfDNA Webinar Series to learn more about the use of ccfDNA in oncology research and techniques to maximize results.

Nucleic Acid Extraction

Our easy-to-use nucleic acid purification reagents cover a full range of sample throughput needs—from manual solutions through benchtop automation to plate-based systems for high-throughput processing. Learn about automated DNA and RNA extraction from FFPE tumor samples, and miRNA purification from tissue, plasma or serum.

Clinical Research

With many urgent challenges and uncertain outcomes, molecular oncology research requires comprehensive support and resources. We believe in science-driven solutions and personalized service for scientists working with any type of cancer research. Explore our collection of molecular oncology resources, or chat with a scientist to work through your specific needs.


Microsatellite Instability
MSI status is an important biomarker for immunotherapeutic response in cancer patients, making it an increasingly relevant tool in genetic- and immune-oncology. We currently offer microsatellite instability testing products for research use globally, and for IVD use in certain countries throughout Europe.

The latest addition to our portfolio is the new LMR MSI Analysis System, a PCR-based method for re-evaluating challenging tumor samples to determine true microsatellite instability status. The longer base-pair shifts exhibited by the LMR system allow you to make a more confident assessment of MSI status, especially in extracolonic cancer tumors which tend to have fewer and smaller shifts in loci.

Instruments

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New CE System for Fragment Analysis and Sanger Sequencing

The Spectrum Compact CE System is a Sanger sequencing instrument used in oncology research applications for molecular profiling of cancers. It can be used to detect and verify the presence of mutant alleles in tumor tissue.

Register for Online DemoView Instrument in 3D
GloMax Discover System Multimode Plate Reader

High-Performance Microplate Reader

GloMax® plate readers have high sensitivity and wide dynamic range, so you can accurately detect high and low signals on the same plate. Easily detect luminescence, fluorescence, absorbance, BRET and FRET with the touch of a button!

Register for Online Demo
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Benchtop Automated Nucleic Acid Purification

Maxwell® Instruments are compact, automated nucleic acid purification platforms that process up to 48 samples simultaneously. Get high-quality nucleic acid purification with minimal steps and less hands-on time!

Register for Online Demo

Posters

Reproducible, MoA-Reflecting Reporter-Based Bioassays to Enable Drug Development of Biosimilars and Biobetters
Presented by: Brad Swanson

Download the PDF

A Homogenous PBMC ADCC Bioassay Enables Bridging Studies with ADCC Reporter Bioassays in Immunotherapy Monoclonal Antibody Development
Presented by: Gopal Krishnan

Download the PDF

Improved DAMP Assays for the In Vitro Assessment of Immunogenic Cell Death
Presented by: Andrew Niles

Download the PDF

An Integrated Workflow for Microsatellite Instability with a Novel MSI Panel
Presented by: Samantha Lewis

Download the PDF

Novel Bioluminescent Bioassays for the Discovery and Development of Molecular and Cellular T Cell-Redirecting Cancer Therapy
Presented by: Vanessa Ott

Download the PDF

Cell-Based Reporter Bioassays for the Development of Fc-Functional and Fc-Silent SIRPa/CD47 Checkpoint Inhibitors
Presented by: Jamison Grailer

Download the PDF

MoA-Based Potency Bioassays for Immunotherapy Programs Targeting Immune Checkpoint Receptors
Presented by: Zhi-Jie (Jey) Cheng

Download the PDF

Have Questions?

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