Protein and lipid kinases are involved in a wide variety of pathological conditions. Accordingly, kinase biology constitutes a critical field for drug discovery research. Bioluminescent assays that measure the transfer of phosphate from ATP to cellular substrates enable rapid screening of inhibitors, selectivity profiling and pathway analysis in high-throughput formats.
Kinase Biology Resources
Automating the Kinase Profiling Systems
Learn how to use Promega kinase assays for rapid screening of compound libraries.
ADP-Glo: A Luminescent ADP Detection Assay for Kinases
In vitro studies of the mode of action of kinase inhibitors, and drug resistance mechanisms of mutated kinases.
Application of BRET Technology to Quantitatively Determine Kinase Inhibitor Potency in Live Cells
Discover how a collaboration between Promega and Reaction Biology Corporation has enabled conversion of kinase target engagement assays into a service compatible with high-throughput cell-based profiling.