Kinase Biology for Drug Discovery
Protein and lipid kinases are involved in a wide variety of pathological conditions. Accordingly, kinase biology constitutes a critical field for drug discovery research. Bioluminescent assays that measure the transfer of phosphate from ATP to cellular substrates enable rapid screening of inhibitors, selectivity profiling and pathway analysis in high-throughput formats.
Kinase Biology Resources
Automating the Kinase Profiling Systems
Learn how to use Promega kinase assays for rapid screening of compound libraries.
ADP-Glo: A Luminescent ADP Detection Assay for Kinases
In vitro studies of the mode of action of kinase inhibitors, and drug resistance mechanisms of mutated kinases.
A Quantitative Technique to Measure Kinase Target Engagement in Live Cells
In this webinar we report the use of an energy transfer technique (NanoBRET) in the first quantitative approach to profiling kinase occupancy of a test compound inside live cells.