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Secondary Screening and Lead Optimization

Assays to assist with your lead generation and optimization needs such as receptor and signaling pathway targets, target engagement, HDACs, glucose uptake and other metabolite detection reagents, glycosyltransferase activity, and inflammasome activation. You will also find the same cell-based assays for real-time cell viability & cytotoxicity.

46 Products


Application


Target Class


Technique

Shop all Secondary Screening and Lead Optimization

NanoBRET™ TE Intracellular Kinase Assay

Quantitative live-cell target engagement assay for direct measurement of kinase-ligand affinity and residence time.

N2520, N2521, N2540, N2501, N2500, N2530

Luciferase Pathway Reporters

Prebuilt luciferase vectors and cell lines for studying signaling pathways.

NanoBRET™ Target Engagement HDAC Assays

Directly measure HDAC-test compound affinity and residence time in live cells.

N2080, N2081, N2170, N2090

Glucose Uptake-Glo™ Assay

Non-radioactive assay for measuring glucose uptake.

J1341, J1342, J1343

MTase-Glo™ Methyltransferase Assay

Measure methyltransferase activity using a universal bioluminescent assay.

V7601, V7602

GTPase-Glo™ Assay

Simple, sensitive detection of GTPase, GAP and GEF activities.

V7681, V7682

Nano-Glo® Dual-Luciferase Reporter Assay System

Ultra-sensitive detection of firefly and NanoLuc® luciferase activities in a single sample.

N1610, N1620, N1630, N1650, N1521, N1531, N1541, N1551

ONE-Glo™ EX Luciferase Assay System

Improved ONE-Glo™ Assay. Higher sensitivity, long-lived luminescence, more storage options.

E8110, E8120, E8130, E8150

RealTime-Glo™ MT Cell Viability Assay

A bioluminescent method to kinetically monitor viability in cell culture up to 72 hours.

G9711, G9712, G9713

UDP-Glo™ Glycosyltransferase Assay

A universal, "add-incubate-read" assay for glycosyltransferase activity.

V6961, V6962, V6963, V6971, V6972, V6981, V6982, V6991, V6992, V7051, V7052, V7061, V7062

CellTiter-Glo® 3D Cell Viability Assay

A homogeneous method optimized to assess viability in 3D cell culture.

G9681, G9682, G9683

HDAC-Glo™ Class IIa and HDAC-Glo™ 2 Assays

Detects HDAC Class IIa and Class I enzyme 2 activity.

G9560, G9590

NanoBRET™ Target Engagement Assay Components

For use with all NanoBRET™ TE (BET BRD, HDAC and Kinase) Assays.

N2150, N2120, N2161, N2160, N2191, E4881

CellTiter-Glo® 2.0 Assay

Improved reagent stability over the classic CellTiter-Glo® Assay for determining cell viability.

G9241, G9242, G9243

Nicotinamide Adenine Dinucleotide Cell-Based Assays

Sensitive, bioluminescent assays to detect NAD(P)+ and NAD(P)H levels in cells.

G9071, G9072, G9081, G9082

Showing 46 of 46 Products

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