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CRISPR Ready-to-Use Knock-in Reporter Cells

CRISPR-engineered cell lines with a bioluminescent tag fused to the target of interest provide a convenient and quantifiable method for studying endogenous protein abundance. Live-cell assays using these cell lines enable the study of protein dynamics in real time.

Promega continues to expand our collection of HiBiTNanoLuc®, and HaloTag® CRISPR knock-in cell pools and clones, including both N and C-terminal fusions to many popular drug targets. Knock-ins are performed in common workhorse cell lines and, in many cases, the cell background that is most relevant to the biology being studied. Let our experts take care of the cell engineering so you can focus on your research goals.

Pools and Clones Options

prebuilt2

Pre-built & Purchasable
Ships in 1-3 weeks.

development2

In Development
May take up to 3 months to ship.

customizable2

Custom
Tell us your research needs.

Cell Line Pools and Clones

We offer a large selection of pre-built and in-development CRISPR knock-in cell lines. Search the table below to find your target or cell background of interest. Cell lines in development are indicated by asterisks (*).

Search List

Target Tag Terminus Background Clone/Pool
ADRB2* HiBiT N HEK293 C
AKT1* HiBiT C HeLa C/P
AKT1* HiBiT C Jurkat C/P
AKT1* HiBiT C K-562 C/P
ANKRD37* HiBiT C HeLa C/P
AR* HiBiT C LNCaP clone FCG C
AR(V7) HiBiT C 22Rv1 C
ARID1A HiBiT N ES-2 P
ARID1A HiBiT C ES-2 P
ARID1B HiBiT N TOV-21G P
ARID1B HiBiT C TOV-21G P
ARRB2* HiBiT C U-937 C/P
ARRB2* HiBiT C HEK293 C/P
ARRB2* HiBiT C PC-3 C/P
AURKA HiBiT C PC-3 P
AXL* HiBiT C HeLa C/P
BNIP3* HiBiT C HeLa C/P
BRAF* HiBiT N A-549 C
BRAF HiBiT N A-549 P
BRAFV600E HiBiT N A375 C
BRAFV600E* HiBiT C A375 C/P
BRD2 HiBiT N HEK293 LgBiT C
BRD3* HiBiT N HEK293 LgBiT C
BRD4 HiBiT N HEK293 LgBiT C
BRD4 NanoLuc N HEK293 C
BRD4 HiBiT-HaloTag N HEK293 LgBiT C
BRD4* HiBiT-HaloTag N HEK293 C/P
BRD4 HiBiT N HEK293 C
BRD4 HiBiT N PC-3 P
BRD7 HiBiT C HEK293 C/P
BRD7* HiBiT N HEK293 LgBiT C
BRD7 HiBiT N HEK293 LgBiT P
BRD7* HiBiT C HEK293 LgBiT C/P
BRD7* HiBiT C Jurkat LgBiT C/P
BRD7* HiBiT C HeLa LgBiT C/P
BRD9* HiBiT C HEK293 LgBiT C/P
BRD9 HiBiT C HEK293 C/P
BRD9* HiBiT N HEK293 LgBiT C
BRD9 HiBiT N HEK293 LgBiT P
BRD9* HiBiT N Jurkat LgBiT C/P
BTK HiBiT C PC-3 P
CASP3* HiBiT C HeLa C/P
CBL-B HiBiT C Jurkat C/P
CDK1* HiBiT C HEK293 C/P
CDK1* HiBiT C K562 C/P
CDK10* HiBiT C HEK293 C/P
CDK10* HiBiT C K-562 C/P
CDK11* HiBiT N HEK293 C/P
CDK11* HiBiT N K-562 C/P
CDK12* HiBiT C HEK293 C/P
CDK12* HiBiT C K-562 C/P
CDK13* HiBiT C HEK293 C/P
CDK13* HiBiT C K-562 C/P
CDK14* HiBiT N HEK293 C/P
CDK15* HiBiT C HEK293 C/P
CDK16* HiBiT C HEK293 C/P
CDK16* HiBiT C K-562 C/P
CDK17* HiBiT C HEK293 C/P
CDK17* HiBiT C K-562 C/P
CDK18* HiBiT C HEK293 C/P
CDK2 NanoLuc C HEK293 C
CDK2 HiBiT C HEK293 C
CDK2* HiBiT C K-562 C/P
CDK4 NanoLuc N K-562 C
CDK4* HiBiT N HEK293 C/P
CDK4* HiBiT C HEK293 P
CDK4 NanoLuc N T-47D C
CDK4* HiBiT N K-562 C/P
CDK5* HiBiT C HEK293 C/P
CDK5* HiBiT C K-562 C/P
CDK6 NanoLuc N K-562 C
CDK6* HiBiT C HEK293 C
CDK6* HiBiT C K-562 C/P
CDK7* HiBiT N HEK293 C/P
CDK7* HiBiT N K-562 C/P
CDK8* HiBiT N HEK293 C/P
CDK8* HiBiT N K-562 C/P
CDK9 HiBiT N HEK293 C
CDK9* HiBiT C HEK293 P
CDK9* HiBiT N K-562 C/P
CFL1* HiBiT C HeLa C/P
CREBBP HiBiT C U-2 OS P
CSNK1A1 HiBiT C HEK293 LgBiT C/P
CSNK1A1* HiBiT N HEK293 LgBiT P
CTNNB1* HiBiT C HeLa C
CTNNB1 HiBiT N HEK293 LgBiT C
CTNNB1* HaloTag-HiBiT C HEK293 C/P
CTNNB1 HaloTag-HiBiT C HEK293 LgBiT C
EGFR* HiBiT N HeLa C
EGFR* HiBiT C HeLa C/P
EP300 HiBiT C U-2 OS P
ERBB3(HER3) NanoLuc C AU565 C
ERN1(IRE1)* HiBiT C HEK293 C/P
ESR1(ER)* HiBiT C HEK293 C/P
ESR1(ER)* HiBiT C MCF7 C/P
EZH2* HiBiT C HEK293 LgBiT C/P
EZR* HiBiT C HeLa C/P
FANCM HiBiT C HEK293 LgBiT P
FOS* HiBiT C K-562 C/P
GAPDH* HiBiT C HeLa C/P
GSK3b* HiBiT C K-562 C/P
GSK3b* HiBiT C Jurkat C/P
GSK3b* HiBiT C HeLa C/P
GSPT1 HiBiT N HEK293 LgBiT C/P
HDAC2* HiBiT C HeLa C/P
HDAC6* HiBiT C HeLa C/P
HIF1A* HiBiT C HeLa C
HILPDA* HiBiT C HeLa C/P
HMOX1* HiBiT N A-549 C
IKZF1(Ikaros) HiBiT C Jurkat LgBiT C/P
IKZF2(Helios)* HiBiT C Jurkat LgBiT C
IKZF2(Helios) HiBiT C Jurkat LgBiT P
IKZF2(Helios) HiBiT N Jurkat LgBiT C/P
IKZF3(Aiolos)* HiBiT N MM.1S C
IKZF3(Aiolos) HiBiT N MM.1S P
IL2* HiBiT C Jurkat C
IL17RA* HiBiT C HeLa P
IRAK3 NanoLuc N THP-1 C
IRAK4 HiBiT C HeLa C
IRAK4* HiBiT C Jurkat C/P
IRAK4* HiBiT C K-562 C/P
IRAK4 HiBiT C K-562 LgBiT C
JAK1* NanoLuc C THP-1 C/P
JAK1* NanoLuc C K-562 C/P
JAK1* NanoLuc C HEK293 C/P
JAK2* NanoLuc C TF-1 C
JAK2(V617F) HiBiT C Hel92.1.7 C
JAK2(V617F) NanoLuc C Hel92.1.7 C
JUN* HiBiT C HeLa C
KDM4A* NLuc-HaloTag N HCC827 C
KLF10* HiBiT C HeLa C/P
KRas(G12S) HiBiT N A-549 C
KRas(G12C) HiBiT N MIA PaCa-2 C
KRas(G12D) HiBiT N AsPC-1 C
KRas(G12D)* HiBiT N SW1990 C
KRas(G12V) HiBiT N SW620 C
KRas(G13D) HiBiT N NCI-H647 C
KRas(WT) HiBiT N NCI-H1299 C
KRas(WT) HiBiT N HEK293 C
MAP4K1(HPK1) NanoLuc N Jurkat C
MAP4K1(HPK1) HiBiT N Jurkat C/P
MAP4K3(GLK)* HiBiT N Jurkat LgBiT C/P
MAPK14 NanoLuc C HEK293 C
MAPK8* HiBiT C K-562 C/P
MAPT(Tau 3R) HiBiT N IMR-32 C
MARC_1 HiBiT C HEK293 C
MET* HiBiT C HeLa C
Myc (cMyc) HiBiT C HEK293 LgBiT C
Myc (cMyc)* HiBiT C HEK293 C/P
NFE2L2(NRF2) HiBiT N A-549 C/P
NFE2L2(NRF2)* HiBiT N NCI-H1944 C/P
NFE2L2(NRF2) HiBiT N NCI-H460 C
NFKB1A* HiBiT C HeLa C/P
NRAS(WT) HiBiT N HEK293 C
NRAS(WT)* HiBiT N Hs936.T C
NTN4(NETRIN-4) HiBiT C DLD1 P
PARP1* HiBiT C HeLa C/P
PAX8 HiBiT N NIH:OVCAR-3 P
PLCG1* HiBiT C K-562 C/P
POLQ NanoLuc C DLD1 P
POLQ NanoLuc N DLD1 P
PRKCA* HiBiT C HeLa C/P
PTK2* HiBiT C K-562 C/P
RAF1 (cRAF) HiBiT C A-549 C/P
RIPK1* HiBiT C HeLa C/P
RIPK1* HiBiT C K-562 C/P
RIPK1* HiBiT C Jurkat C/P
SALL4* HiBiT N SK-N-DZ C
SALL4 HiBiT C SK-N-DZ C
SMAD3* HiBiT-HaloTag N THP-1 C
SMARCA2 HiBiT C HeLa C/P
SMARCA4 HiBiT C HeLa C/P
SMARCA4* HiBiT C HeLa LgBiT C
SMARCA4 HiBiT C HeLa LgBiT P
STAT3* HiBiT C K-562 C
STAT3 HiBiT C HeLa LgBiT C
SUCLA-2* HiBiT C 22Rv1 C
TEAD2 HiBiT N HEK293 C
TEAD2* HiBiT N HEK293 P
TNFRSF1A HiBiT C HeLa P
TREM2 HiBiT N THP-1 C
TREM2 HiBiT C THP-1 C
TYROBP(DAP12) HiBiT C THP-1 C
UBB (Polyubiquitin-B)* HaloTag N HEK293 LgBiT C/P
USP14 HiBiT C HEK293 LgBiT C/P
USP14 HiBiT N HEK293 LgBiT P

Would you like an offline copy of this table?

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Ordering Options

Contact us to get started with the cell lines you need or to stay updated on our growing list of available knock-in cell lines.

2020 07 CRISPR Cell Line Inquiry
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