Accurate Target Identification
Precisely identify proteins that interact with target compounds using HaloTag® technology—a comprehensive platform for functional protein analysis. This protein technology rapidly captures interacting proteins from live cells and features:
- Potency and permeability of tagged small molecules remains unchanged when captured using a novel chloroalkane tag.
- Protein targets are captured in live cells, ensuring relevancy of results when interactions occur under conditions relevant to the desired cellular phenotype.
- Enrichment method allows capture of low-abundance and low-affinity targets through efficient capture of the chloroalkane-tagged compound onto immobilized HaloTag® Protein.
Read more about the HaloTag® protein capture technology in the paper "Deciphering the cellular targets of bioactive compounds using a chloroalkane capture tag." Ohana, R.F., et al. (2015) ACS Chem. Biol. 10, 2316–24.