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Trypsin Platinum, Mass Spectrometry Grade

Recombinant Trypsin with Maximum Digest Sensitivity

  • Maximum resistance to autoproteolysis
  • Each lot qualified by mass spectrometry to ensures compatibility with your applications/instrumentation
  • Recombinant protease free of nonspecific cleavage activity
  • Available as early access material; please contact us for more information.

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This product is discontinued
Trypsin Platinum, Mass Spectrometry Grade

Native trypsin used for the characterization of proteins by mass spectrometry includes the presence of low but detectable chymotrypsin contaminating activity. Native trypsin also contains relatively high levels of autoproteolytic peptides generated during protein digestion.

Trypsin Platinum, Mass Spectrometry Grade, is a recombinant protease manufactured to provide maximum specificity. 

Comparison of Nonspecific Digestion

Trypsin activity comparison
A model antibody (Panitumumab) was digested at 1:10 trypsin:protein ratio overnight at 37°C and analyzed with reverse-phase HPLC-UV using A) native Trypsin Mass Spectrometry Grade or B) new recombinant Trypsin Platinum.

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