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Large-Volume Nucleic Acid Extraction

We offer a line of purification chemistries for extraction of nucleic acids from various sample types on robotic liquid handlers, and provide consultative services to design and implement these chemistries on automated systems.

Automated systems are typically designed to process samples in 96 well formats. This limits well volumes to 2ml or less and working volumes to less than 1.2ml when considering shaking plates or using magnetic particle movers. For applications seeking to process larger amounts of samples a larger sample well is required.  The Heater Shaker Magnet (HSM) increases the capabilities of automated liquid handlers to allow processing of larger volume samples in 50ml conical tubes. The HSM can be used with many different purification chemistries.

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HSM Basics

The Heater Shaker Magnet Instrument (HSM 2.0) provides all-in-one processing capabilities for large-volume purification chemistries in manual or automated formats. The HSM is used with liquid-handling systems to provide fully automated extraction of DNA from large-volume blood samples.

The Heater Shaker Magnet (HSM 2.0) is designed to perform all the functions necessary for processing magnetic resin-based purification chemistries in large-volume formats. Paramagnetic resin chemistries typically require mixing, heating and a mechanism to efficiently capture the particles. By combining the ability to heat, shake and apply a magnetic field, the HSM 2.0 Instrument provides all-in-one processing capabilities for a variety of large-volume purification chemistries in either manual or automated formats. The instrument uses standard 50ml conical tubes and reagent-based paramagnetic particle (PMP) chemistries. Within PMP-based chemistries the PMPs provide a mobile solid phase that optimizes capture, washing and elution of biological target molecules.

Initially designed to run the Promega ReliaPrep™ Large Volume HT gDNA Isolation System, the HSM 2.0 Instrument is supplied with software containing pre-programmed isolation methods for processing up to 32 samples of human whole blood in approximately 2–3.5 hours, depending on sample volume and number. Samples are processed in a semi-automated method with the user dispensing and aspirating reagents from the samples as directed by the software on a computer screen. The programmed methods control the shaking, heating, magnetization and timing of the steps required for the semi-automated purification. For fully automated purification, the HSM 2.0 Instrument can be integrated with a robotic liquid-handling workstation.