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Maxwell® RSC 48 Instrument

Automated Nucleic Acid Purification of 1 to 48 Samples

  • High-quality nucleic acid purification with minimal steps and less hands-on time
  • Purifies 1–48 samples in a single run
  • Intuitive software and integrated vision system for detecting and preventing deck tray setup errors


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Maxwell® RSC 48 Instrument
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Extract high-quality nucleic acids with less hands-on time

The Maxwell® RSC 48 Instrument is a compact, automated nucleic acid purification platform that processes up to 48 samples simultaneously. Using Maxwell® RSC prefilled cartridges, the Maxwell® RSC 48 Instrument brings the same consistent, reliable purification of DNA or RNA from a variety of sample types and a higher throughput. The intuitive graphical interface makes the instrument easy to use. The integrated vision system with its large LED indicator reduces the potential for user error by detecting proper cartridge placement and lets you know before a run starts if there is an issue. An integrated Bar Code reader makes it easy to track samples.


Focus on the work you want to

There never seems to be enough time to do what you need to in the lab. Watch these researchers explain how they rely on the Maxwell® Instruments to save time on DNA and RNA extraction so they can focus on what matters to them.

Francis Crick Institute Case Study:

Benchtop Automated Nucleic Acid Purification

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It saves me in total about 40 minutes per 12 samples, and I do 4 runs per day, so that is almost half a day.

Yan Tsou, Laboratory Research Scientist

Anthony Nolan Research Institute Case Study:

Long-Read Next-Generation Sequencing Workflow

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It really is the workhorse of our lab in terms of DNA extraction… allowing us to process multiple samples at once with minimal hands-on time.

Thomas Turner, Senior Post Doctoral Research Scientist

No drips, plugs or sample loss with a paramagnetic particle mover

The Maxwell® RSC DNA or RNA extraction methods start with cartridges prefilled with purification reagents and paramagnetic particles, ready for your samples. After sample addition, the Maxwell® RSC moves the paramagnetic particles and associated nucleic acids through multiple steps ultimately yielding highly pure RNA or DNA in 30–100µl.

Because the Maxwell® RSC is a magnetic particle mover, not a liquid handler, it offers advantages over other automated systems. There is minimal risk of cross-contamination because no liquid handling or splashing happens during sample processing. With no clogs and fewer breakdowns, there are fewer disruptions to your workflow.


Easy-to-use interface simplifies your RNA or DNA extraction workflow


Track samples easily

The integrated barcode reader records important information such as sample ID, kit ID and kit lot number.


Touch screen to begin the process

The intuitive touch screen interface lets you easily set up your purification run.


Prepare sample cartridges

Place prepared cartridges in the Maxwell® RSC 48. Press “Start” to purify 1–48 samples using the selected kit’s preprogrammed method.


Start run with confidence

The integrated vision system detects proper cartridge setup along with a large LED indicator and audible alarm, giving you confidence your extraction is running smoothly.

Works with multiple sample types

DNA Extraction

DNA purified with the Maxwell® RSC System is compatible with a wide range of downstream applications such as Sanger and next generation sequencing, arrays and digital PCR.


Maxwell® RSC Whole Blood DNA Kit »
Extracts DNA from larger sample sizes (up to 500µl) of whole blood without preprocessing

Maxwell® RSC Blood DNA Kit »
Extracts higher yields of DNA from up to 300µl of whole blood following Proteinase K treatment

Maxwell® RSC Buffy Coat DNA Kit »
Extract DNA from 50–250µl of buffy coat samples.

Saliva Tubes

Maxwell® RSC Stabilized Saliva DNA Kit »
Extracts DNA from stabilized saliva tubes


Maxwell® RSC Tissue DNA Kit »
Extract DNA from up to 50mg of mammalian tissues samples.

Fecal Samples

Maxwell® RSC Fecal Microbiome DNA Kit »
Extracts DNA from human and mammalian feces.

Buccal Swabs

Maxwell® RSC Buccal Swab DNA Kit »
Extracts DNA from buccal swab


Maxwell® RSC DNA FFPE Kit »
Extracts DNA from formalin-fixed paraffin embedded (FFPE) tissue sections

Maxwell® FFPE Plus LEV DNA Purification Kits »
Extracts DNA from FFPE samples with comparable performance to the Maxwell® 16 DNA FFPE LEV Plus Kit


Maxwell® RSC ccfDNA Plasma Kit »
Extracts ccfDNA from plasma

Maxwell® RSC Viral Total Nucleic Acid Purification Kit »
Extracts viral total nucleic acid (RNA and DNA) from serum, plasma and other samples

Casework Samples

Maxwell® FSC DNA IQ™ Casework Kit »
Extracts DNA from Forensic Casework Samples


Maxwell® RSC Cell DNA Purification Kit »
Extracts DNA from samples containing less than 10,000 cells such as amniotic fluid, cerebral spinal fluid and cell supernatants

Maxwell® RSC Cultured Cells DNA Kit »
Extracts DNA from Mammalian or bacterial cultured cell samples in about 45 minutes.

Plants and Food

Maxwell® RSC Plant DNA Kit »
Extracts DNA from a range of plant sample types including soybean, corn and Arabidopsis

Maxwell® RSC PureFood GMO and Authentication Kit »
Extracts DNA from a wide range of food sample types including soybean, corn, canola, fish, beef and pork

Maxwell® RSC PureFood Pathogen Kit »
Extracts bacterial DNA from a wide range of food sample types for use in NGS, serotyping and identification of spoilage organisms

RNA Extraction

RNA purified with the Maxwell® RSC System is compatible with downstream applications, such as RT-PCR.


Maxwell® RSC simplyRNA Blood Kit »
Purifies total RNA from 2.5ml of fresh whole blood


Maxwell® RSC simplyRNA Cells Kit »
Purifies total RNA from fresh or frozen cells


Maxwell® RSC RNA FFPE Kit »
Extracts RNA from formalin-fixed paraffin embedded (FFPE) tissue sections


Maxwell® RSC simplyRNA Tissue Kit »
Purifies total RNA from up to 20mg of tissue

Maxwell® RSC miRNA Tissue Kit »
Purifies total RNA, including miRNA, from mammalian tissue samples


Maxwell® RSC Viral Total Nucleic Acid Purification Kit »
Extracts viral total nucleic acid (RNA and DNA) from serum, plasma and other samples

Maxwell® RSC miRNA Plasma and Serum Kit »
Purifies high-quality, amplifiable miRNA from plasma, serum or enriched exosomes


Maxwell® RSC Plant RNA Kit »
Extracts RNA from a range of plant sample types including soybean, corn and Arabidopsis

Instrument Specifications

Processing Time: 30–70 minutes (depending on sample type and method)

Sample Capacity: 1–48 Samples; (2) 24 position, removable trays

Dimensions: (W × D × H): 21 × 21 × 14 inches (533 .4 × 533.4 × 355.6 mm)

Weight: ~60 lbs (~27 kg)

Main Power Voltage: 100–240V AC, 50/60Hz; autosensing; 4 Amps

Operating Environment: 15–25°C

Service and Warranty: 1-year limited warranty on parts and labor. Extended service contracts

UV-Bulb: Average lifetime approximately 9,000 hours, length 212.1mm, diameter 16mm, 6W, 0.17A current, 42V, spectral peak F 253.7, UV output 1.7W

Instrument Standard Components


A. Maxwell® RSC 48 Instrument

B. Tablet PC preloaded with Maxwell® RSC 48 Application Software

C. Power Supply for Tablet PC (Power Cord for Tablet PC provided separately)

D. USB Cable - Maxwell® RSC 48 Instrument to Tablet PC

E. Power Cable for Maxwell® RSC 48 Instrument (provided separately)

F. Maxwell® RSC 48 Deck Trays (2)

G. Hand held barcode reader

H. USB cable for connection of the Maxwell® RSC 48 Instrument to the barcode reader

UV Bulb (installed)

Quick Start Guide

Setup Guide

Service and Support

One Call Supports It All

One Call Supports It all

Promega supplies both the reagents and the instrument, so one call to Promega answers any questions you may have about assay chemistries or instrument performance.

Contact Technical Services
Ensure Minimal Instrument Downtime

Ensure Minimal Instrument Downtime

  • Field Support and Loaner Programs
  • Service Packages
  • IQ and OQ Packages
Warranty and Service Agreements

Warranty and Service Agreements

  • Backed by a one-year warranty.
  • Additional warranty and service agreements are available.
  • For more information contact Promega Technical Services.

Accessories Available Separately

Additional deck trays, plungers and an optional bar code reader are available for purchase separately.


Certificate of Analysis

Search by lot number

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions


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