We believe this site might serve you best:

United States

United States

Language: English

Promega's Cookie Policy

Our website uses functional cookies that do not collect any personal information or track your browsing activity. When you select your country, you agree that we can place these functional cookies on your device.

Our website does not fully support your browser.

We've detected that you are using an older version of Internet Explorer. Your commerce experience may be limited. Please update your browser to Internet Explorer 11 or above.

Microplate Readers are now 20% off! Click to learn more about how you can save!

MEK Inhibitor U0126


Inhibits Activation of MAPK (ERK 1/2)

  • Used in both in vivo and in vitro studies of MEK
  • Potent: inhibits Raf-activated MEK1/2 in vitro with an IC50 of ~10–20μM
  • Supplied as a dried material


Catalog number selected: V1121

$ 242.00
Your price:
Add to Cart
This product is discontinued
Add to Helix
MEK Inhibitor U0126
$ 242.00
Your price: Log in

MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). U0126 inhibits MEK1 with an IC50 of 0.5μM (in vitro). It has been used in both in vivo and in vitro studies of MEK. The chemical identity of MEK Inhibitor U0126 has been confirmed by proton NMR spectroscopy.

Supplied as a dried material. Resuspend 1mg in 234μl of DMSO to produce a stock solution of 10mM.


  1. DeSilva, D.R. et al. (1998) J. Immunol. 160, 4175–81.
  2. Favata, M. et al. (1998) J. Biol. Chem. 273, 18623–32.
  3. Goueli, S. et al. (1998) Promega Notes 69, 6–8.
  4. Tolwinski, N.S. et al. (1999) J. Biol. Chem. 274, 6168–74.
  5. Li, C. et al. (1999) J. Biol. Chem. 274, 6747–53.
  6. Duncia, J.V. et al. (1998) Bioorg. Med. Chem. Lett. 8, 2839–44.


What's in the box?

Item Part # Size

MEK Inhibitor U0126

V112A 5 × 1mg


Choose language:

Download SDSPDF (40 KB) – English (United States)

Certificate of Analysis

Search by lot number

Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions


Store dried material at –20°C.

Let's find the product that meets your needs.

Talk to a Scientist