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MEK Inhibitor U0126

Inhibits Activation of MAPK (ERK 1/2)

  • Used in both in vivo and in vitro studies of MEK
  • Potent: inhibits Raf-activated MEK1/2 in vitro with an IC50 of ~10–20μM
  • Supplied as a dried material

Size

Catalog number selected: V1121

$ 230.00 Your price: Log In

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MEK Inhibitor U0126
5mg
$ 230.00
Your price: Log In

MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). U0126 inhibits MEK1 with an IC50 of 0.5μM (in vitro). It has been used in both in vivo and in vitro studies of MEK. The chemical identity of MEK Inhibitor U0126 has been confirmed by proton NMR spectroscopy.

Supplied as a dried material. Resuspend 1mg in 234μl of DMSO to produce a stock solution of 10mM.

References

  1. DeSilva, D.R. et al. (1998) J. Immunol. 160, 4175–81.
  2. Favata, M. et al. (1998) J. Biol. Chem. 273, 18623–32.
  3. Goueli, S. et al. (1998) Promega Notes 69, 6–8.
  4. Tolwinski, N.S. et al. (1999) J. Biol. Chem. 274, 6168–74.
  5. Li, C. et al. (1999) J. Biol. Chem. 274, 6747–53.
  6. Duncia, J.V. et al. (1998) Bioorg. Med. Chem. Lett. 8, 2839–44.

Protocols

Specifications

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Item Part # Size

MEK Inhibitor U0126

V112A 5 × 1mg

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Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

BB

Store dried material at –20°C.

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