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InCELLect™ AKAP St-Ht31 Inhibitor Peptide

Inhibits interaction between RII subunits of cAMP-Dependent Protein Kinase (PKA) and AKAP

  • Cell permeable, allowing for in vivo studies on PKA localization
  • Used with the InCELLect™ St-Ht31 Control Peptide to study the role of AKAP in mediating PKA responses

Size

Catalog number selected: V8211

$ 400.00 Your price: Log In

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InCELLect™ AKAP St-Ht31 Inhibitor Peptide
150μl
$ 400.00
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Analyze Cellular Signaling Reactions in Vivo

InCELLect™ AKAP St-Ht31 Inhibitor Peptide is a stearated (St) form of the peptide Ht-31 derived from the human thyroid AKAP (A-kinase anchoring protein). This peptide inhibits the interaction between the RII subunits of cAMP-Dependent Protein Kinase (PKA) and AKAP in cell extracts. The presence of the hydrophobic stearated moiety enhances the cellular uptake of the peptide through the lipophilic microenvironment of the plasma membrane. InCELLect™ St-Ht31P Control Peptide, which has a similar sequence but does not inhibit the interaction between protein kinase A and AKAP, has been used as a control peptide for studies with InCELLect™ AKAP St-Ht31 Inhibitor Peptide.

Properties:

  • Concentration: 10mM in 50mM Tris-HCl (pH 7.5).
  • Purity: >80% by HPLC.
  • Molecular Weight: 2,797±3 a.m.u.

Optimal concentration and incubation times will need to be determined for each experimental system. Reference 1 describes the inhibitory effects for the InCELLect™ AKAP St-Ht31 Inhibitor Peptide in the range of 5–50μM within 3–5 minutes after treatment.

References:

  1. Vijayaraghavan, S. et al. (1997) J. Biol. Chem. 272, 4747–52.
  2. Vijayaraghavan, S. et al. (1997) Biol. Reprod. 56, 1450–7.
  3. Klussmann, E. et al. (1999) J. Biol. Chem. 274, 4934–8.

Specifications

What's in the box?

Item Part # Size

InCELLect™ AKAP St-Ht31 Inhibitor Peptide

V821A 1 x 150μl

SDS

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Use Restrictions

For Research Use Only. Not for Use in Diagnostic Procedures.

Storage Conditions

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