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Promega Corporation

Mouse ADCC Bioassays

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MOA) of antibodies that target virus-infected or diseased (e.g., tumor) cells for destruction by components of the cell-mediated immune system. Mouse FcγRIV (mFcγRIV) is the predominant receptor involved in ADCC in the mouse and is more closely related to human FcγRIIIa, the primary Fc receptor involved in ADCC in humans, than mFcγRIII.

The mFcγRIV ADCC Reporter Bioassay is a biologically relevant MOA-based assay that can be used to measure the activity of mouse antibodies that specifically bind and ...

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  • *Prices valid for US customers only
Product Size Conc. Catalog # *List Price QTY Add to Cart

mFcγRIV ADCC Reporter Bioassay, Complete Kit

1 each
- M1201 $ 890.00 Add to cart

mFcγRIV ADCC Reporter Bioassay, Core Kit

1 each
- M1211 $ 775.00 Add to cart

mFcγRIV ADCC Reporter Bioassay, Core Kit 5X

1 each
- M1215 $ 3,490.00 Add to cart

mFcγRIV ADCC Bioassay Effector Cells, Propagation Model

1 each
- M1212 Please Enquire

Storage Conditions

Note: The mFcγRIV ADCC Reporter Bioassay components are shipped separately because of temperature requirements. The mFcγRIV Effector Cells and Target Cells (Raji) are shipped on dry ice. The Bio-Glo™ Luciferase Assay System and Low IgG Serum are shipped on dry ice, separately from the cells. The RPMI 1640 Medium is shipped at ambient temperature. The Control Ab, Anti-CD20, is shipped on gel ice.

Upon arrival, immediately transfer the cell vials to storage below –140°C (freezer or liquid nitrogen vapor phase) for long-term storage. Do not store cell vials submerged in liquid nitrogen. Do not store cell vials at –80°C because this will negatively affect cell viability and cell performance. Store Bio-Glo™ Luciferase Assay Substrate, Bio-Glo™ Luciferase Assay Buffer and Low IgG Serum at –20°C. Avoid multiple freeze-thaw cycles of the serum. For optimal performance, use reconstituted Bio-Glo™ Luciferase Assay Reagent on the day of preparation. However, once reconstituted, you can store Bio-Glo™ Luciferase Assay Reagent at –20°C for up to 6 weeks. Store Control Ab, Anti-CD20 at 4°C. Store RPMI 1640 Medium at 4°C protected from fluorescent light.

For product intended use please see Patents & Disclaimers tab.

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