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$500 credit for you & your colleagues

Developing innovative therapeutics requires commitment. Commitment to discovery. Commitment to quality. Commitment to process.

Navigating the long, increasingly complex process requires equally committed partners both inside and outside your company.

Introduce your colleagues to a partner that provides quality, leading-edge technologies backed by unparalleled scientist-to-scientist support. Give your colleagues a $500 Promega credit, and we’ll give you a $500 credit on your next order for every colleague who becomes a Promega customer.

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*Terms and conditions may apply. Qualifying purchases are limited to products featured in product explorer. $500 credit can only be applied to one order.

Explore the
Biologics Toolkit


Use this guide to find resources and technologies that support antibody therapeutics research and development.

Follow the Analytical Characterization Tools path to find technologies that lead to more precise large molecule characterization.

Navigate Functional Bioassays to find the latest cell-based reporter bioassays to help you stay on the leading edge of the rapid evolution of therapeutic strategies.

Biologics Tool Kit

Analytical Tools


Development of antibody-based therapeutics requires quantitative MOA-based bioassays during all stages of drug research and development. If your interests include peptide mapping, glycan analysis or stability testing of large protein molecules explore our portfolio assays.

Biologics Tool Kit

Tools by Therapeutic Approach


Incorporating commercially available assays, with industry standard technologies can help your program advance more quickly and efficiently. Explore Promega's growing Bioassay portfolio.

Biologics Tool Kit

Fc Effector Activity


Traditional killing assays using primary cells are highly relevant. However, this type of assay can be problematic in environments with high quality control requirements.

Promega's Fc Effector Reporter Bioassays correlate with traditional killing assays, meet  ICH qualification guidelines, and replace highly variable primary cells with a stable Jurkat clone expressing the appropriate FcγR receptor with NFAT elements that drive luciferase expression.

Biologics Tool Kit

T Cell Retargeting


Bi-specific antibodies can be used to redirect T cells to kill tumor cells and assays to monitor this effect usually focus on either T cell activation or Target cell killing. Promega’s T cell activation bioassays shorten the time and reduce the variability associated with traditional readouts such as proliferation and cytokine production, while the Target cell specific assays provide for a larger assay window by eliminating the measurement of signals coming from non-Target cells.

T Cell Activation Bioassays

Target Cell Specific Killing Assays

Biologics Tool Kit

Immune Checkpoint Modulation


Immune checkpoint modulation has proven to be a successful approach in oncology treatment.

Promega has a suite of luciferase based reporter assays to measure agonist antibodies designed to bind and activate co-stimulatory molecules or blocking antibodies designed to stimulate T cells via blocking co-inhibitory signals.

Biologics Tool Kit

Cytokine Modulation


Therapeutics designed to either enhance or block cytokine activity have traditionally been measured using primary cells with readouts that may include proliferation, FACS, and ELISAs. While physiologically relevant, these assays may suffer from variability and complex workflows.

Employing a luciferase based reporter assay offers the advantage of a simplified, homogenous workflow with high data quality.  Promega has a rapidly growing portfolio of cytokine and growth factor bioassays.

Biologics Tool Kit

Antibody Drug Conjugates


Antibody Drug Conjugates (ADC) aim to take advantage of the specificity of monoclonal antibodies (mAbs) to deliver potent cytotoxic drugs selectively to antigen-expressing tumor cells. Promega offers a suite of robust and reproducible assays to monitor the key attributes of ADC including internalization and cell health in real-time or endpoint. Cell Health assays include toxicity, viability, cellular metabolism, and apoptosis.

Biologics Tool Kit

Why Partner with Promega


Promega is a global leader and partner in providing innovative solutions and technical support. Promega’s Functional Bioassays methodology is designed to develop robust assays with a minimum amount of work. We maintain a robust pipeline of bioassays in development and seek to partner with drug developers in the early stages to ensure that our bioassays meet the needs of our customers. Explore the benefits of partnering with Promega.

Biologics Tool Kit

Antibody Purification and Conjugation


Antibody Drug Conjugates (ADC) are designed to selectively kill tumor cells via delivery of potent cytotoxic drugs. Promega offers a suite of robust and reproducible assays to monitor the key attributes of ADC including internalization and cell health in real-time or endpoint. Cell Health assays include toxicity, viability, cellular metabolism, and apoptosis.

Biologics Tool Kit

Antibody and Antigen Internalization


Antibody Drug Conjugates (ADC) are designed to selectively kill tumor cells via delivery of potent cytotoxic drugs. Promega offers a suite of robust and reproducible assays to monitor the key attributes of ADC including internalization and cell health in real-time or endpoint. Cell Health assays include toxicity, viability, cellular metabolism, and apoptosis.

Biologics Tool Kit

Endpoint and Kinetic Cell Health Assays


Antibody Drug Conjugates (ADC) are designed to selectively kill tumor cells via delivery of potent cytotoxic drugs. Promega offers a suite of robust and reproducible assays to monitor the key attributes of ADC including internalization and cell health in real-time or endpoint. Cell Health assays include toxicity, viability, cellular metabolism, and apoptosis.

Biologics Tool Kit

Characterization


Our collection of proteases and other protein analysis reagents for biologics testing include antibody-specific proteases such as IdeS and IdeZ, a variety of general proteases (i.e. g trypsin or Lys-C), and glycosidases. We also have pH-reactive dyes for antibody internalization assays and systems for capture and purification.

Biologics Tool Kit

Proteases/Glycosylases


Our collection of proteases and other protein analysis reagents for biologics testing include antibody-specific proteases such as IdeS and IdeZ, and a variety of general proteases (i.e. g trypsin or Lys-C), glycosidases. We also have pH-reactive dyes for antibody internalization assays and systems for capture and purification.

Biologics Tool Kit

Bioanalytical/PK


Improve protein sample prep workflow with rapid digestion, improved sequence coverage and more data from minimal sample material.

Biologics Tool Kit

Purification


Rapid, simple and robot-friendly antibody purification beads and systems for your manual and automated purification needs.

Biologics Tool Kit

Reference Materials


Characterize proteins and antibodies, study glycosylation, perform digestions faster using alternative proteases and trypsin. Find mass spec reference reagents to quantify and qualify your mass spec instruments.

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