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We have many tools available to help you understand PROTAC™ kinetics and mode of action. Please mark which areas you want to investigate, and a representative from our team will contact you to discuss your options for getting started.
I want to measure the abundance of target proteins using lytic or live-cell assays.
         · NanoLuc® or HiBiT fusion vectors
         · Intracellular LgBiT expression options for live-cell analysis of HiBiT
         · Guidance for CRISPR tagging of target protein
I want to measure PROTAC cell permeability and binding.
         · NanoBRET™ TE In-Cell CRBN Kit
         · NanoBRET™ TE In-Cell VHL Kit
         · NanoLuc®-VHL HEK293 Stable Cell Line
         · Kinase and Epigenetic Tracers
I want to measure ternary complex formation in cells.
         · NanoBRET™ E3 Ligase CRBN Interaction Assay
         · NanoBRET™ E3 Ligase VHL Interaction Assay
         · HEK293 HaloTag®-VHL Stable Cell Line
         · HEK293 HaloTag®-CRBN Stable Cell Line
         · NanoBRET™ BRD4/CRBN Interaction Assay
         · NanoBRET™ BRD/VHL Interaction Assay and Stable Cell Line
         · Additional HaloTag®-E3 ligase constructs (~320)
I want to measure ubiquitination of my target protein.
         · NanoBRET™ Ubiquitin Interaction Assay
         · NanoBRET™ BRD4/Ub Interaction Assay
         · NanoBRET™ β-catenin/Ub Interaction Assay
I want to measure recruitment of my target protein to the proteasome.
         · NanoBRET™ Proteasome Interaction Assay
         · NanoBRET™ BRD4/PSMD3 Interaction Assay and Stable Cell Line
         · NanoBRET™ cMyc/PSMD3 Interaction Assay
         · NanoBRET™ β-catenin/PSMD3 Interaction Assay
Please Describe Your Interest in a Custom Assay or Provide Additional Comments
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