The use of therapeutic antibodies targeting immune checkpoints for the treatment of cancers is gaining momentum and has already shown promising clinical results. However, the functional screening and development of drug candidates often relies on the use of human primary immune cells which use methods that are tedious and highly variable, and are therefore technically challenging to implement.
Reporter gene assays offer the advantage to be robust, extremely fast, and easy to implement and transfer between global sites. They are widely adopted in controlled drug development environment. In this webinar, we will discuss the development of a series of MoA-based reporter gene bioassays for therapeutic antibodies targeting immune inhibitory receptors (PD-1, CTLA-4, TIGIT, LAG3), immune co-stimulatory receptors (4-1BB, OX40, GITR, CD40, HVEM, CD27), or combination bioassays targeting two immune checkpoint receptors (PD-1+TIGIT, PD-1+CTLA4, PD-1+LAG3). We will show case studies on assay design and development, assay optimization with Thaw-and-Use cells, and assay qualification according to ICH guidelines (repeatability, intermediate precision, specificity and linearity). Please join us to learn more about how reporter gene bioassays can facilitate the antibody screening and development in immunotherapy program.
Zhijie Jey Cheng, PhD
Senior Research Scientist
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