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How much are you paying for your reverse transcriptase?

 

  • Promega’s MMLV RNase H minus point mutant is the same enzyme used in many branded reverse transcriptase preparations.

  • RNase H minus status gives long read length for full length cDNA.

  • High temperature stability to overcome secondary structure.

  • Higher Yields than other M-MLV variants.

 

< Comparision of Promega’s M-MLV RT, RNase H Minus, Point Mutant (P) and SuperScript™ II (S) for synthesis of full length cDNA from a 7.5kb RNA. First-strand cDNA reactions were performed using a 7.5kb RNA template (1µg in 1µl), 0.5µg of oligo(dT)15 and 15.25µl of water in a 0.5ml microcentrifuge tube heated at 70˚C for 5 minutes. The reactions were then cooled on ice for 5 minutes before adding 5µl of M-MLV RT 5X Buffer, 1.25µl of 10mM dNTPs, 0.5µl [α-32P dCTP] (10µCi/µl, 400Ci/mmol), and 200 units of reverse transcriptase. The reactions were incubated at 40˚C for 50 minutes. Samples were then separated on an alkaline agarose gel and autoradiography was performed.

Compare these prices to see if you are getting the best value:

Quantity Superscript™ II Reverse Transcriptase Promega M-MLV RNase H Minus, Point Mutant
2,500 Units Ł41.25 Ł20
10,000 Units Ł145.00 Ł94
50,000 Units Ł662.50 Ł405

Prices are based on catalogue list prices as of 12th May 2008, where no direct equivalent pack size is available prices have been extrapolated from the nearest equivalent pack size.

 

 

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Promega M-MLV RNase H minus points mutant.