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Go Luminescent!  Get rid of what bugs you about your ADME assays

A Bright New Approach

Promega’s range of ADME systems are designed to harness the power of bioluminescence to bring you assays that are not influenced by cellular or compound autofluorescence or excitation photon interference. As a result our bioluminescent solutions offer greater sensitivity (up to 4 logs) compared to fluorescent methods.

ADME Screening Early in Drug Discovery
The ability to determine the ADME properties of new chemical entities early in the drug discovery process would reduce late stage failures, saving time and money, and aid better drug design.

Promega offers cell-based and enzyme assays which would enable biologically relevant data to be collected early in the discovery process. Systems are available for:

Cytochrome P450s
P-glycoprotein (Pgp)Monoamine oxidase (MAO)Request More Information
 

Why switch to Bioluminescence?

The Physics of Bioluminescence assures that our assays are not influenced by cellular autofluorescence, compound autoflourescence or excitation photon interference.

With fluorescence the excitation wavelength light overlaps with the emission light reducing sensitivity.

When viewed on a log scale the difference in how the excited state is created translates up to 4 logs greater sensitivity for bioluminescence relative to fluorescence.

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