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Abstract for PDE-Glo™ Phosphodiesterase Assay
The PDE-Glo™ Phosphodiesterase Assay is a luminescent,
high-throughput screening method for measuring cyclic nucleotide
phosphodiesterase (PDE) activity from purified sources. PDEs have
been implicated in a variety of diseases such as erectile dysfunction,
asthma, chronic obstructive pulmonary disease, learning disorders,
depression and memory functions, neurodegenerative diseases, autoimmune
disorders, heart failure and myocardial infarction. The availability of
selective inhibitors for PDEs has facilitated their use as tools to
study cyclic nucleotide signaling and paved the way to investigate the
role of PDEs in cellular and tissue pathologies. The PDE-Glo™
Phosphodiesterase Assay allows lead candidates for PDE inhibitors to
be identified.
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