Abstract for p450-Glo™ Screening Systems
Part# TB340
Printed in USA. Revised 6/09.
Instructions for Use of Products
V9770,
V9790,
V9800,
V9880,
V9890,
V9910 &
V9920.
The P450-Glo™ Screening Systems provide a complete set of reagents
for performing luminescent cytochrome P450 assays. The systems include a
membrane preparation containing recombinant human cytochrome P450
enzyme, a luminogenic cytochrome P450 substrate appropriate for the
enzyme, an NADPH Regeneration System, reaction buffer, Luciferin
Detection Reagent and Luciferin-Free Water. The membranes are prepared
from baculovirus-infected insect cells and contain human cytochrome P450
and P450 reductase (and cytochrome b5 for CYP2C9 and CYP3A4). The
P450-Glo™ Screening Systems also contain a membrane fraction devoid of
cytochrome P450 activity as a negative control. The assays are ideal for
testing the effects of drugs and new chemical entities on cytochrome
P450 enzyme activities.
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