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Abstract for PPase-2A
Protein Phosphatase-2A (PPase-2A) is a serine/threonine phosphatase that was
purified based on its ability to dephosphorylate the a-subunit
of phosphorylase kinase. With its 36-38kDa catalytic subunit, PPase-2A has
broad substrate specificity and may play a regulatory role in DNA replication,
transcription, protein synthesis, mitosis and glycogen metabolism. PPase-2A
is stimulated in vitro by basic proteins such as protamine, histones and
polylysine. The enzyme is inhibited by several environmental toxins and
tumor promoters such as okadaic acid and microcystin-LR. Promega's
PPase-2A Catalytic Subunit is isolated from rabbit skeletal muscle.
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