Aubert, J., Dessolin, S., Belmonte, N., Li, M., McKenzie, F.R., Staccini, L., Villageois, P., Barhanin, B., Vernallis, A., Smith, A.G., Ailhaud, G. and Dani, C.
Notes: The effect of the U0126, MEK Inhibitor is reported and compared to that of the inhibitor PD98059. PD98059 inhibited an Erk-dependent glycerol-phosphate dehydrogenase activity by 60% at 10µM. The same inhibition was seen with U0126 at 0.5µM. Also, 10µM PD98059 produced 50% inhibition of LIF-stimulated C/EBP gene expression whereas 10µM U0126 completely prevented the expression (no other concentrations of U0126 reported). (1484)