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Proc. Natl. Acad. Sci. USA 96, 12679-84. The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components. 1999

Lee, B.N., and Elion, E.A.

Notes: The involvement of mitogen-activated protein kinase kinase kinase kinase (Ste20), MAPKKK (Ste11), MAPKK (Ste7), and transcription factor (Ste12) under the basal conditions of vegetative growth of yeast was examined. Saccharomyces cerevisiae protein was subjected to Western blot analysis with the Anti-ACTIVE® MAPK Ab (1:1500 dilution) to monitor levels of active MAPK. (2399)

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J. Biol. Chem. 273, 31273-31282. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. 1998

Ogawa, S. , Oku, A. , Sawano, A. , Yamaguchi, S. , Yazaki, Y. , Shibuya, M.

Notes: Used Anti-ACTIVE® MAPK pAb to analyze extent of Erk activation in NIH3T3-KDR cells treated with VEGF-E. (0591)

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Am. J. Physiol. 274, C789-C798. Activation of p42mapk in human umbilical vein endothelial cells by interleukin-1 alpha and tumor necrosis factor-alpha. 1998

May, M.J., Wheeler Jones, C.P., Houliston, R.A., Pearson, J.D.

Notes: The authors used the Anti-ACTIVE® MAPK pAb for immunoblot assays with human vein endothelial cells. (0706)

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J. Biol. Chem. 273, 31408-31416. Activation of signal transducers and activators of transcription 1 and 3 by leukemia inhibitory factor, oncostatin-M, and interferon-gamma in adipocytes. 1998

Stephens, J. M., Lumpkin, S. J., Fishman, J. B.

Notes: The authors used the Anti-ACTIVE® MAPK pAb to detect activation of Erk in cytosolic extracts of 3T3-L1 adipocytes following treatment with insulin. (0334)

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J. Biol. Chem. 273(1), 28-32.. Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. 1998

Rui, H., Xu, J., Mehta, S., Fang, H., Williams, J., Dong, F., and Grimley, P.M.

Notes: The MTT-based CellTiter 96® Non-Radioactive Cell Proliferation Assay was used to measure the viability of serum-deprived prolactin-dependent Rat lymphoma Nb2 cells cultured in the presence of ovine prolactin and aurintricarboxylic acid (ATA). ATA was demonstrated to stimulate growth of Nb2 cells and protect against staurosporine-induced apoptosis. Promega’s Anti-ACTIVE™ MAPK pAb was used on Western blots to demonstrate that ATA stimulates phosphorylation of MAPK. (1702)

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J. Biol. Chem. 273, 28-32. Activation of the Jak2-Stat5 signaling pathway in Nb2 lymphoma cells by an anti-apoptotic agent, aurintricarboxylic acid. 1998

Rui, H. , Xu, J., Mehta, S., Fang, H., Williams, J., Dong, F., Grimley, P.M.

Notes: The CellTiter® 96 Non-Radioactive Cell Proliferation Assay (MTT) was used to measure the proliferative response of quiescent Nb2 pre-B-cell lymphoma cells (40,000 cells/well) to control media, ovine prolactin and aurintricarboxylic acid (ATA). Nb2 cells proliferated in response to ATA, and ATA was found to activate ERK2. ATA at 250µM activated ERK2 within 4min as shown by blots with the Anti-ACTIVE® MAPK pAb. (0464)

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Am. J. Physiol. 275, H641-H652. Alpha1-adrenergic activation of myocardial Na-K-2Cl cotransport involving mitogen-activated protein kinase. 1998

Andersen, G.O., Enger, M., Thoresen, G.H., Skomedal, T. and Osnes, J.B.

Notes: The authors used the Anti-ACTIVE® MAPK pAb for Western blots with rat heart tissue samples. (1511)

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Proc. Natl. Acad. Sci. USA 95, 15547-15552. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. 1998

Naramura, M., Kole, H.K., Hu, R.J. , Gu, H.

Notes: The Anti-ACTIVE® MAPK pAb was used to analyze the extent of MAPK activation in thymocytes from wildtype and c-cbl deficient mice following stimulation with anti-CD3epsilon antibody. (0646)

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Blood 91, 1548-1555. Both stroma and stem cell factor maintain long-term growth of ELM erythroleukemia cells, but only stroma prevents erythroid differentiation in response to erythropoietin and interleukin-3 1998

O'Prey, J., Leslie, N., Itoh, K., Ostertag, W., Bartholomew, C., Harrison, P.R.

Notes: The CellTiter 96® Non-Radioactive Cell Proliferation Assay was used to assess the growth factor requirements of murine erythroleukemia cells in culture. The cells were cultured for five days with various cytokines and growth factors prior to assay. Several of the IGF-1 independent clones analyzed by western blotting with the Anti-ACTIVE® MAPK pAb were found to have a constitutive level of activated MAP Kinase. Study also shows serum is a very potent activator of MAPK in serum-starved cells. (0567)

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Blood 91(5), 1548-55. Both stroma and stem cell factor maintain long-term growth of ELM erythroleukemia cells, but only stroma prevents erythroid differentiation in response to erythropoietin and interleukin-3. 1998

O'Prey, J., Leslie, N., Itoh, K., Ostertag, W., Bartholomew, C. and Harrison, P. R.

Notes: The MTT-based CellTiter 96® Non-Radioactive Cell Proliferation Assay was used to assess the effects of IGF-I, insulin or Stem Cell Factor (SCF) on growth of murine erythroleukemia cells. The effects of neutralizing antibodies against the growth factors were also tested. Promega’s Anti-ACTIVE® MAPK pAb, with specificity for the active, dually phosphorylated form of MAPK was used for Western blotting to assay activation of mitogen-activated protein (MAP) kinases. Several of the IGF-1 independent clones analyzed by western blotting and found to have a constitutive level of activated MAP Kinase. Serum was shown to be a potent activator of MAPK in serum-starved cells. (2080)

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Proc. Natl. Acad. Sci. USA 95, 14500-5. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. 1998

Meucci, O., Fatatis, A., Simen, A.A., Bushell, T.J., Gray, P.W., Miller, R.J.

Notes: Authors studied the effect of chemokines on signaling pathways in primary rat hippocampal neuron cultures. Used Anti-ACTIVE® MAPK, JNK, and p38 pAbs for western analysis of extracts derived from pure (glial free) hippocampal neuron cultures. (0685)

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J. Biol. Chem. 273, 21099-21104. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). 1998

Furuchi, T.and Anderson, R.G.W.

Notes: Serum-starved Rat-1 cells were incubated in absence or presence of 2% cyclodextrin for 1hr followed by ncubation in the presence of EGF for various times from 0-10min. Dually phosphorylated MAPK was detected in the caveolae after 3min and in the cytosol fraction by 5min using the Anti-ACTIVE® MAPK pAb. (1132)

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J. Biol. Chem. 273, 16487-16493. Conditional, tissue-specific expression of Q205L Gαi2 in vivo mimics insulin activation of c-Jun N-terminal kinase and p38 kinase. 1998

Guo, J.H., Wang, H. and Malbon, C.C.

Notes: Mice were administered a dose of insulin, and at various time-points, the gastrocnemius muscle was removed and homogenized. Activation of ERK1 and ERK2 was detected 8 minutes following insulin administration. The activated ERK1 and ERK2 were detected with the Anti-ACTIVE® MAPK pAb by immunoblotting and chemiluminescent detection. (1086)

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J. Immunol. 160, 4153-4157. Cutting edge: IL-4 induces functional cell-surface expression of CXCR4 on human T cells. 1998

Jourdan, P., Abbal, C., Noraz, N., Hori, T., Uchiyama, T., Vendrell, J.P., Bousquet, J., Taylor, N., Pène, J., Yssel, H.

Notes: Stromal-derived factor 1 and an anti-CD3 antibody induced Erk dual phosphorylation Th1 clone HY-243 cells cultured in the presence of IL-2 and IL-4. With IL-2 alone, only anti-CD3 induced ERK dual phosphorylation. The activation of ERK was assessed by Western blotting with the Anti-ACTIVE® MAPK pAb. (0950)

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Neuron 21, 681-63. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. 1998

Meyer-anke, A., Wilkinson, G.A., Kr

Notes: The authors used Anti-ACTIVE® MAPK pAb (V6671) for Western analysis at a final concentration of 10ug/ml, with total cell lysates of Retinal Ganglion Cell and Superior Cervical Ganglion Neurons. (0687)

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J. Biol. Chem. 273, 35250-35259. Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation. 1998

Raffioni, S., Zhu, Y.Z., Bradshaw, R.A. , Thompson, L.M.

Notes: The authors used Anti-ACTIVE® MAPK pAb to perform westerns on PC12 extracts. (0528)

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J. Biol. Chem. 273, 35000-35007. Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera. 1998

Carter, R. E. , Sorkin, A.

Notes: In this paper, the authors used Promega's Anti-ACTIVE® MAPK pAb for Western analysis using NIH3T3 cell extracts. (1349)

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J. Neurosci. 18, 8814-8825. Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. 1998

Sgambato, V., Pages, C., Rogard, M., Besson, M.J , Caboche, J.

Notes: Used Anti-ACTIVE® MAPK pAb for western analysis of brain extracts (1:2500 dilution) and immunohistochemistry of brain tissue sections (1:100 dilution). (0426)

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Am. J. Respir. Cell Mol. Biol. 18, 562-569.. Hydrogen peroxide activates extracellular signal-regulated kinase via protein kinase C, Raf-1 and MEK1. 1998

Abe, M.K., Kartha, S., Karpova, A.Y., Li, J., Liu, P.T., Kuo, W.-L. and Hershenson, M.B.

Notes: Bovine tracheal myocytes were treated with hydrogen peroxide and the level of MAPK phosphorylation was determined by Western blotting of the cell lysates with the Anti-ACTIVE® MAPK pAb. Pretreatment of the cells with the hydroxyly radical scavenger MPG significantly reduced the level of activation. Pretreatment of the cells with heavy metal chelator o-phenanthroline had very little effect. (2051)

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Am. J. Physiol. 275, H131-H138. Inhibition of p42 and p44 MAP kinase does not alter smooth muscle contraction in swine carotid artery. 1998

Gorenne, I. , Su, X. , Moreland, R. S.

Notes: Authors use the Anti-ACTIVE® MAPK pAb in Western blots and kinase studies on swine carotid arteries. (1112)

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Proc. Natl. Acad. Sci. USA 95, 14540-14545. Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion. 1998

Pillinger, M.H., Capodici, C., Rosenthal, P., Kheterpal, N., Hanft, S., Philips, M.R., Weissmann, G.

Notes: Used Anti-ACTIVE® MAPK pAb for western analysis of neutrophil extracts following stimulation with FMLP, arachidonic acid, or phorbol esters and aspirin or sodium salicylate (the latter two of which inhibit Erk activation). Used 125I -labeled Protein A for detection. (0534)

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J. Immunol. 161, 3803-3807. Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148. 1998

Tangye, S.G., Wu, J., Aversa, G., de Vries, J.E., Lanier, L.L., Phillips, J.H.

Notes: The authors transfected Jurkat cells with wildtype and phosphatase-deficient CD148 (a receptor-type protein-tyrosine phosphatase) to observe the effect this had on the activation of T cells and the MAPK signaling pathway. Activation of MAPK was monitored by Western analysis using Promega's Anti-ACTIVE MAPK® pAb. (0302)

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J. Neurosci. 18, 10420-10428. p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. 1998

Klesse, L.J., Parada, L.F.

Notes: The authors used Anti-ACTIVE® MAPK pAb for Western analysis of mouse dorsal root ganglion neurons that had been infected with various adenoviral vectors expressing wildtype, dominant negative, or constitutively active variants of proteins in the ras/erk pathway. (0907)

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J. Immunol. 160, 4841-4849. Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets. 1998

Smith, J. A., Tang, Q., Bluestone, J. A.

Notes: The authors used the Anti-ACTIVE® MAPK pAb for western analysis of the MAPK signal transduction pathway in Th1 and Th2 T cell clones following activation of the T cell receptor by FcR-nonbinding anti-CD3 mAb. (0380)

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J. Neurosci. 18, 3480-87. Phosphorylation of mitogen-activated protein kinase by one-trial and multi-trial classical conditioning. 1998

Crow, T., Xue-Bian, J.J., Siddiqi, V., Kang, Y., and Neary J.T.

Notes: In sea slugs (Hermissenda crassicornis) the protein kinase C pathway is involved in short- and long-term memory associated with multi-trial Pavlovian conditioning. The authors examine the activation of MAPK pathway by one-trial and multi-trial conditioning in Hermissenda eyes and proximal optic nerves. The dually phosphorylated, active MAPK was detected by Western blot using the Anti-ACTIVE® MAPK pAb. (2398)

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