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J. Cell Biol. 139(4), 1017-1023. Lack of correlation between activation of Jun-NH2-terminal kinase and introduction of apoptosis after detachment of epithelial cells. 1997

Khwaja, A. and Downward, J.

Notes: The CellTiter 96® AQueous (MTS/PMS) Non-Radioactive Cell Proliferation Assay was used to measure dose-response Z-VAD-FMK inhibition of apoptosis of MDCK cells by measuring cell survival. The effect of treatment with Z-VAD-FMK on cell survival in response to detachment (suspension for 12 hours, then re-platting) was measured. (2098)

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Blood 89(5), 1507-1512. Leptin stimulates fetal and adult erythroid and myeloid development 1997

Mikhail, A.A., Beck, E.X., Shafer, A., Barut, B., Gbur, J.S., Zupancic, T.J., Schweitzer, A.C., Coiffi, J.A., Lacaud, G., Ouyand, B., Keller, G. and Snodgrass, H.R.

Notes: Recombinant leptin was demonstrated to stimulate an increase in cell number of murine yolk sac and fetal liver cells. The authors reported measuring relative cell number using the MTS assay from Promega. (2076)

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EMBO J. 16, 2783-2793. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. 1997

Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H., Downward, J.

Notes: The CellTiter® 96 AQueous Non-Radioactive Cell Proliferation Assay was used to measure the cell survival of wildtype and transfected MDCK cells following detachment from matrix. (0939)

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Blood 90(9), 3456-3461. Mechanisms of stem cell factor and erythropoietin proliferative co-signaling in FDC2-ER cells. 1997

Joneja, B., Chen, H-C., Seshasayee, D., Wrentmore, A.L. and Wojchowski, D.M.

Notes: The CellTiter® 96 AQueous Non-Radioactive Cell Proliferation Assay was used to measure the mitogenic responsiveness of hematopoietic progenitor (FDC2-ER) cells to erythropoietin (Epo) and stem cell factor (SCF). (2092)

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Biochemistry 36, 6033-6045. Modified antisense oligonucleotides directed against tumor necrosis factor receptor type I inhibit tumor necrosis factor alpha-mediated functions 1997

Ojwang, J.O., Mustain, S.D., Marshall, H.B., Rao, T.S., Chaudhary, N., Walker, D.A., Hogan, M.E., Akiyama, T., Revankar, G.R., Peyman, A., Uhlmann, E, Rando, R.F.,

Notes: The CellTiter 96® AQueous Assay (MTS/PMS) was used to measure the cytotoxicity limits of an antisense oligonucleotide of the TNF receptor I. The highest concentration of oligonucleotide that could be transfected without killing the cells was used for subsequent studies. (0598)

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Biochemistry 36(20), 6033-6045. Modified antisense oligonucleotides directed against tumor necrosis factor receptor type I inhibit tumor necrosis factor alpha-mediated functions. 1997

Ojwang, J.O., Mustain, S.D., Marshall, H.B., Rao, T.S., Chaudhary, N., Walker, D.A., Hogan, M.E., Akiyama, T., Revankar, G.R., Peyman, A., Uhlmann, E. and Rando, R.F.

Notes: The MTS-based CellTiter 96® AQueous One Solution System was used to measure the cytotoxicity limits of an antisense oligonucleotide of the TNF receptor I. The highest concentration of oligonucleotide that could be transfected without killing the cells was used for subsequent studies. (2079)

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J. Clin. Invest. 99, 1897-1905. Molecular basis of autosomal dominant neurohyposphyseal diabetes insipidus: Cellular toxicity caused by the accumulation of mutant vasopressin precursors within the endoplasmic reticulum. 1997

Ito, M., Jameson, J.L., Ito, M.

Notes: Mutant and wildtype arginine vasopressin (AVP) constructs were co-transfected with a CAT-expression vector containing a neo resistance gene. Stable transformants of Neuro2A cells were generated with the aid of the Transfectam® Reagent and G418 sulfate. CAT activity in stably transfected clones was determined with the CAT Enzyme Assay System. The effect of the mutant AVP constructs on cell viability was determined with the CellTiter 96® AQueous Cell Proliferation Assay (MTS/PMS). Several constructs displayed marked decreases in cell viability. The cause was necrosis rather than apoptosis due to the absence of DNA laddering and a negative reaction in the Apoptosis Detection System, Fluoroscein (data not shown). The name of the Apoptosis Detection System, Fluorescein, has changed to DeadEnd™ Fluorometric TUNEL System. (1009)

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Cancer Res. 57(19), 4325-4337. Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. 1997

Pederson, L.C., Buchsbaum, D.J., Vickers, S.M., Kancharla, S.R., Mayo, M.S., Curiel, D.T. and Stackhouse, M.A.

Notes: The MTS-based CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure the effects of viral infection-induced sensitivity to production of 5-fluorouracil on the human cholangiocarcinoma cell line SK-ChA-1. (2081)

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J. Neurosci. 17, 530-542. Nerve growth factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors. 1997

Muragaki, Y., Chou, T.T., Kaplan, D.R., Trojanowski, J.Q. and Lee, V.M.-Y.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure the viability of medulloblastoma cells (+/- human TrkA) cultured in the presence of NGF for four days. (1519)

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Genes Dev. 11(20), 2633-2644. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. 1997

Mancebo, H.S.Y., Lee, G., Flygare, J., Tomassini, J., Luu, P., Zhu, Peng, J., Blau, C., Hazuda, D., Price, D. and Flores, O.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay (MTS/PMS) was used to measure the cytotoxicity (IC-50 values) of 11 kinase inhibitors on a Jurkat cell line transfected with HCMV enhancer-luciferase reporter construct. (2070)

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J. Biol. Chem. 272(36), 22751-22757. Retinoblastoma protein-dependent growth signal conflict and caspase activity are required for protein kinase C-signaled apoptosis of prostate epithelial cells. 1997

Zhao, X., Gschwend, J.E., Powell, C.T., Foster, R.G., Day, K.C., and Day, M.L.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was mentioned for determining the viability of prostate epithelial cells to study the balance among various signalling mechanisms of apoptosis. (1731)

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J. Biol. Chem. 272(39), 24684-24690. Role of janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. 1997

Marrero, M.B., Schieffer, B., Li, B., Sun, J., Harp, J.B. and Ling, B.N.

Notes: The MTS-based CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure the effects of anti-STAT, anti-ERK1, and anti-MEK1 antibody electroporation on angiotensin II and PDGF stimulation of rat aortic vascular smooth muscle cells. (2074)

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J. Biol. Chem. 272, 18990-18999. Specific Activation of Retinoic Acid Receptors (RARs) and Retinoid X Receptors Reveals a Unique Role for RARgamma in Induction of Differentiation and Apoptosis of S91 Melanoma Cells 1997

Spanjaard, R. A., Ikeda, M., Lee, P. J., Charpentier, B., Chin, W. W., Eberlein, T. J.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay (MTS/PMS) was used to measure the proliferation of S91 cells. The TNT® Coupled Reticulocyte Lysate System was used to translate the retinoic acid receptor and the retinoid X receptor. These were then assayed in gel shifts. The recombinant human AP-1 and the AP-1 Consensus Oligonucleotides were used in the gel shift assays as well. (0360)

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J. Biol. Chem. 272(30), 18990-18999. Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells. 1997

Spanjaard, R.A., Ikeda, M., Lee, P.J., Charpentier, B., Chin, W.W., and Eberlein, T. J.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure relative viable cell number of S91 murine melanoma cells. Cells treated for 5 days with different concentrations of various retinoids all showed growth arrest suggesting that retinoic acid receptors (RAR) and retinoid X receptors (RXR), can directly or indirectly inhibit cell proliferation. (1710)

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J. Pharmacol. Exp. Ther. 283(3), 1520-1528. The protective effect of metallothionein against lipid peroxidation caused by retinoic acid in human breast cancer cells 1997

Hurnanen, D., Chan, H.M., Kubow, S.

Notes: Overexpression of metallothionein (MT) is linked to decreased cancer survival. One hypothesis is that MT protects from retinoic acid (RA) induced cytotoxicity by scavenging free radicals. This study compared cell viability in two breast cancer cell lines that differ in basal MT expression and estrogen receptor expression. Cells were pretreated with zinc to induce MT expression and then treated with RA. Cell viability was determined using the Cell Titer 96® AQueous Non-Radioactive Cell Proliferation Assay. (2482)

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Proc. Natl. Acad. Sci. USA 94, 4669-4674. Thrombin cleaves recombinant human thrombopoietin: One of the proteolytic events that generates truncated forms of thrombopoietin 1997

Kato, T., Oda, a., Inagaki, Y., Ohasi, H., Matsumoto, A., Ozaki, K., Miyakawa, Y., Watari, H., Fuju, K., Kokubo, A., Kadoya, T., Keda, Y., Miyazaki, H.

Notes: The authors measured the in vitro TPO activity of thrombin-cleaved rhTPO in FDCP-2 cells expressing human Mp1 by measuring cell proliferation using the CellTiter 96® AQueous Non-Radioactive Cell Proliferaiton Assay. (2487)

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J. Mol. Cell. Cardiol. 29(5), 1321-1330. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: Balance between growth and death signals. 1997

Spryidopoulos, I. Brogi, E., Kearney, M., Sullivan, A.B., Cetrulo, C., Isner, J.M., and Losordo, D.W.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure viability of human umbilical vein endothelial cells (HUVEC) treated with combinations of TNFalpha and VEGF. Viability assays demonstrated that VEGF significantly inhibits apoptosis in TNFalpha-treated HUVEC. (1711)

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Nature 386(6624), 517-521. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. 1997

Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J-L., Schroter, M., Scaffidi, C., Krammer, P.H., Peter, M.E. and Tschopp, J.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to quantify the number of viable E8 expressing Jurkat cells (and non-expressing controls) when incubated with recombinant sTRAIL, an orphan member of the TNF family that is structurally similar to the CD95L. (1714)

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Am. J. Respir. Cell Mol. Biol. 15(3), 348-354. ErbB-2 knockout employing an intracellular single-chain antibody (sFv) accomplishes specific toxicity in erbB-2-expressing lung cancer cells. 1996

Grim, J., Deshane, J., Feng, M., Lieber, A., Kay, M. and Curiel, D.T.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure the effect of expression of the anti-erbB-2 sFv on cell growth kinetics and viability of A549 human lung carcinoma cells. (2120)

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Biochem. Biophys. Res. Commun. 226(3), 935-941. Growth hormone-responsive DT-diaphorase-mediated bioreduction of tetrazolium salts. 1996

Goodwin, C.J., Holt, S.J., Riley, P.A., Downes, S. and Marshall, N.J.

Notes: The authors compared MTT (CellTiter 96® Non-Radioactive Cell Proliferation Assay) and MTS (CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay) tetrazolium salts and report that DT-diaphorase inhibitors abolish MTS but not MTT formazan production. The authors conclude that MTT and MTS/menadione resulted in formazan production via a different electron transfer pathway. (2117)

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Neurodegeneration 5(4), 325-329. Maltol (3-hydroxy-2-methyl-4-pyrone) toxicity in neruoblastoma cell lines and primary murine fetal hippocampal neuronal cultures. 1996

Hironishi, M., Kordek, R., Yanagihara, R. and Garruto, R.M.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to measure and demonstrate the cytotoxic effects of maltol on mouse Neuro 2a, human IMR 32 neuroblastoma cell lines as well as primary murine fetal hippocampal neuronal cultures. By comparing the results of DNA laddering and TUNEL assays, the authors suggest the toxic effects of maltol is mediated through apoptosis. The correlation of these data suggest that the CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay can be used to screen for apoptosis. (2123)

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Neurodegeneration 5, 325-329. Maltol (3-hydroxy-2-methyl-4-pyrone) toxicity in neuroblastoma cell lines and primary murine fetal hippocampal neuronal cultures. 1996

Hironishi, M., Kordek, R., Yanagihara, R., and Garruto, R.M.

Notes: The system was used to measure and demonstrate the cytotoxic effects of maltol on murine Neuro2A, human IMR32 neuroblastoma and primary murine fetal hippocampal neuronal cultures. By comparing the results of DNA laddering and TUNEL assays, the authors suggest the toxic effects of maltol is mediated through apoptosis. The correlation of these data suggest that the CellTiter 96® AQueous Assay System can be used to screen for apoptosis. (1562)

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Am. J. Surg. 171(1), 109-112. Matrix alters the proliferative response of enterocytes to growth factors. 1996

Wolpert, S., Wong, M-L. and Bass, B.L.

Notes: MTS was used to compare growth of rat intestinal epithelial cells plated on collagen I or laminin and stimulated with EGF, IGF-I, TGF alpha and various combinations. (2235)

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Oncogene 13, 73-84. Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells. 1996

Huynh, D.P. and Pulst, S.M.

Notes: CellTiter 96 AQueous Non-Radioactive Cell Proliferation Assay was used to demonstrate that NF2 antisense oligonucleotides significantly increased the number of viable Schwann-like STS26T cells in a proliferation assay. (1564)

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Oncogene 13(1), 73-84. Neurofibromatosis-2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells. 1996

Huynh, D.P. and Pulst, S-M.

Notes: The CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to demonstrate that NF2 antisense oligonucleotides significantly increased the number of viable Schwann-like STS26T cells in proliferation assays. (2089)

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