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Mol. Cell. Biol. 19, 136-146.. Glutamate induces phosphorylation of Elk-1 and cREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. 1999

Vanhoutte, P., Barnier, J.-V., Guibert, B., Pages, C., Besson, M.-J., Hipskind, R.A., Caboche, J.

Notes: The Anti-ACTIVE® MAPK pAb and Anti-ACTIVE® JNK pAb were used to examine whether or not the kinases were activated by glutamate in rat striatal slices via Western blotting. Both were activated and at least MAPK activation could be blocked with MEK inhibitors. CaM KII was also shown to be activated by the glutamate treatment as judged by Western blotting with the Anti-ACTIVE® CaM KII pAb. Interestingly, inhibition of CaM KII activation by the specific inhibitor KN62 also decreased activation of Erk 1 and 2 above control levels in the presence of glutamate. This suggests that CaM KII plays a role in calcium signaling to activate Erk's in this tissue. (0218)

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Eur. J. Biochem. 260, 917-922. Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA. 1999

Klotz, L.-O., Pellieux, C., Briviba, K., Pierlot, C., Aubry, J.-M., Sies, H.

Notes: The Anti-ACTIVE® JNK pAb was used for Western analysis of human skin fibroblast cell extracts following exposure to singlet oxygen and UVA radiation. (0909)

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J. Biol. Chem. 274, 29595-29598. Stress-induced JNK activation is independent of Gadd45 induction. 1999

Shaulian, E., Karin, M.

Notes: NIH-3T3 cells were treated with anisomycin. The treatment activates JNK as judged by immunoblotting with the Anti-ACTIVE® JNK pAb. (0385)

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J. Cell Biol. 146, 361-372. The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway. 1999

Sawamoto, K., Winge, P., Koyama, S., Hirota, Y., Yamada, C., Miyao, S., Yoshikawa, S., Jin, M.H., Kikuchi, A., and Okano, H.

Notes: A Ral GTPase, which regulates developmental changes through inhibition of the JNK pathway, is identified in Drosophila. Inhibition of the JNK pathway in the presence of a constitutively active Ral protein was examined by Western blot using Promega's Anti-ACTIVE® JNK pAb. Drosophila S2 cells were treated with 500 mM sorbitol for 5 min, lysed, subjected to SDS-PAGE, and transferred to nylon membranes. The membranes were incubated with Anti-ACTIVE® JNK to detect the dually phosphorlyated (active) form of JNK. (2385)

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J. Biol. Chem. 274, 35686-35692.. The microtubule binding of tau and high molecular weight tau in apoptotic PC12 cells is impaired because of altered phosphorylation 1999

Davis, P.K., Johnson, G.V.W.

Notes: The Anti-ACTIVE® JNK pAb was used for immunocytochemical detection of dually phosphorylated JNK in NGF/serum cultured and deprived PC12 cells. In the normally cultured cells (NGF and serum present) there was light and diffuse staining for the activated JNK throughout the cytoplasm. Upon NGF and serum withdrawal, the staining for the activated JNK is mostly nuclear and coincident with tau staining. (1257)

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J. Biol. Chem. 274, 158-164. UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells. 1999

Chen, A. , Davis, B. H.

Notes: The authors used Promega's Anti-ACTIVE® JNK pAb to detect dually phosphorylated active JNK in primary rat hepatic stellate cells that had been exposed to UV radiation. (1365)

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Proc. Natl. Acad. Sci. USA 95, 14500-5. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. 1998

Meucci, O., Fatatis, A., Simen, A.A., Bushell, T.J., Gray, P.W., Miller, R.J.

Notes: Authors studied the effect of chemokines on signaling pathways in primary rat hippocampal neuron cultures. Used Anti-ACTIVE® MAPK, JNK, and p38 pAbs for western analysis of extracts derived from pure (glial free) hippocampal neuron cultures. (0685)

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EMBO J. 17, 4404-4413. Differential regulation of c-jun by ERK and JNK during PC12 cell differentiation. 1998

Leppa, S., Saffrich, R., Ansorge, W. and Bohmann, D.

Notes: NGF stimulated PC12 cell extracts were analyzed by Western analysis using the Anti-ACTIVE® JNK pAb. (2036)

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J. Biol. Chem. 273, 29857-29863. Metabolic oxidative stress-induced HSP70 gene expression is mediated through SAPK pathway. Role of Bcl-2 and c-Jun NH2-terminal kinase. 1998

Lee, Y. J. , Corry, P. M.

Notes: The authors used Anti-ACTIVE® JNK pAb for western analysis (1:5000 dilution, ECL detection) to examine the effect of glucose deprivation on JNK activation in MCF-7/ADR cells. (0819)

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J. Biol. Chem. 273, 12203-12209. MyD88, an adapter protein involved in Interleukin-1 signaling. 1998

Burns, K., Martinon, F., Esslinger, C., Pahl, H., Schneider, P., Bodmer, J.L., Di Marco, F., French, L. and Tschopp, J.

Notes: Overexpression of MyD88 acts to inhibit IL-1-mediated JNK activation in a 293T cell line overexpressing the type I IL-1 receptor. Activation of JNK was monitored by Western blot analysis using the Anti-ACTIVE® JNK pAb (1:5000 dilution). Extracts of 293 cells were separated by SDS-PAGE , transferred to nitrocellulose membrane, and blotted to detect only the dually phosphorylated, active forms of JNK. (2035)

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J. Biol. Chem. 273, 32787-32792. Protein Kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line. 1998

St Denis, A., Chano, F., Tremblay, P., St Pierre, Y., and Descoteaux, A.

Notes: The authors examined the effect of overexpressing a dominant negative mutant of protein kinase C alpha in RAW 264.7 cells on LPS induced signal transduction. They used the Anti-ACTIVE® JNK pAb for western analysis and the NF-kappaB oligonucleotide for electrophoretic mobility shift assay (EMSA) analysis of NF-kappaB activation. (0326)

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J. Biol. Chem. 272, 32056-32060. MEKK1 binds directly to the c-Jun N-terminal Kinases/Stress-activated protein kinases 1997

Xu, S. , Cobb, M. H.

Notes: Lysates from 293 cells expressing MEKK1 were analyzed by an in vitro c-jun phosphorylation assay and western blotting using Promega's Anti-ACTIVE® JNK pAb. Levels of activated JNK detected by the antibody directly correlated with that detected by the kinase assay. (0126)

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J. Biol. Chem. 272, 11057-11062. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria.  Efficient synthesis of active protein kinases. 1997

Khokhlatchev, A., Xu, S., English, J., Wu, P., Schaefer, E. and Cobb, M.H.

Notes: This paper describes Western analysis of MAP kinase reconstitution experiments done in E. Coli. The Anti-ACTIVE® JNK pAb was used. (1975)

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