We believe this site might serve you best:

United States

English Continue

This country code will remain if no action is taken to change it.

Don't see your country?
Promega Corporation

A Homogeneous, Single-Addition Bioluminescent Assay for HDAC Class I and II Activities...

A Homogeneous, Single-Addition Bioluminescent Assay for HDAC Class I and II Activities Scientific Poster



Andrew Niles1, Nathan Evans1, Michael A. Scurria2, Tim Ugo2, Gediminas Vidugiris1, and Thomas Kirkland2
1Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711
2Promega Biosciences LLC, 277 Granada Dr., San Luis Obispo, CA 93401

Histone deacetylases (HDACs) play key roles in gene regulation by modifying the acetylation status of core histones as well as a number of non-histone regulatory proteins. Therefore, modulation of HDAC activities represents an emerging paradigm in treating diseases as diverse as cancer, asthma and neurodegeneration. Unfortunately, the biological relationships between specific HDACs and phenotype or disease state are poorly characterized and more effective tools are sought for defining these relationships. Here we describe the assay's utility in relevant cell and enzyme models with a variety of HDAC inhibitory (HDACi)  compounds of varying structure.

Document Icon Download the poster PDF (373kb)

  • Part# PS105
  • Printed in USA.

It appears that you have Javascript disabled. Our website requires Javascript to function correctly. For the best browsing experience, please enable Javascript.

Scientists at Your Service

Scientists at Your Service

We offer a range of services to help you succeed using Promega technologies. From product training to set up of automated systems and development of custom applications—our scientific support goes beyond the basics.

Ask us! We are here to help you.