The ability to better understand the properties of individual compounds is essential in the drug-discovery process. With compound libraries many times numbering in the millions, screening facilities have begun incorporating high-density 1536-well plates in a miniaturized format as a streamlined, cost-effective approach for screening large compound libraries. For this approach to work, they need easy-to-perform assays that are sensitive in a low-volume format. In addition, they need a way to accurately dispense assay components at these volumes.
Promega Notes 92, 7–9.
Brad Larson and Tracy Worzella