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HaloTag® technology is a powerful tool for functional protein analysis based on the formation of a covalent bond between the HaloTag® protein fusion tag and synthetic chemical ligands. By interchanging ligands, you can control the function and properties of the HaloTag® fusion protein, allowing use of the same construct for protein purification, protein interaction analysis, and cell-based assays for protein translocation, receptor internalization, and protein stability studies.
Available HaloTag® ligands include magnetic and non-magnetic beads, glass slides, cell-permeable and impermeable fluorescent ligands, biotin, and reactive ligands that allow you to build your own custom HaloTag® ligands and surfaces.
Efficiently capture proteins expressed in E. coli as HaloTag® fusions.
Purify fusion proteins directly from mammalian cell culture lysates, even at low expression levels.
Perform multicolor live- and fixed-cell imaging experiments using a single genetic construct.
Capture and purify intracellular binary and higher order protein complexes, including transient or weakly interacting partners.
Capture intracellular protein:DNA complexes without using antibodies.
Choose from an extensive library of prebuilt HaloTag® human ORF clones.
Black, J. et al. (2013). Cell, 154 (3), 541-55.
Galbraith et al. (2013). Cell, 153 (6), 1327-39.
Deplus, R. et al. (2013). EMBO J. 32, 645–50.
We offer a range of services to help you succeed using Promega technologies. From product training to set up of automated systems and development of custom applications—our scientific support goes beyond the basics.
Ask us! We are here to help you.