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Promega Corporation

Dr. Tiphaine Mannic Masson

Combined Bioluminescence-Fluorescence Time Lapse Microscopy: Applications to Circadian Rhythm Studies

Abstract

I will first introduce you shortly my research subject, a body-wide web of circadian oscillators and its impact on our physiology and pathophysiology. We will then discuss fluorescence and bioluminescence time-lapse microscopy approach, representing a new era in circadian clock studies and numerous additional questions in cell biology. Finally, specific application of combined bioluminescence-fluorescence time lapse microscopy for human pancreatic islet clock studies will be discussed.

Dr. Mannic Masson started the studies of Cellular and Molecular Biology at Brest University (France), continued to MSc and PhD studies in the Angiogenesis and Vascular Physiopathology laboratory in CEA Grenoble and obtained the PhD from Grenoble University (Doctoral School of Chemistry and Life Sciences-France) in 2009. She did a first postdoctoral study with Dr. Michel Rossier at Geneva University Hospital in Endocrinology, Diabetes, Nutrition and Hypertension department about the effect of aldosterone on the heart. Currently Dr. Mannic Masson works in the same department, in Dr. Charna Dibner’s group. The topic of her research is involvement of circadian rhythms in diabetes and more recently in thyroid tumors.

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