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Bioluminescent Cell-Based Assay Seminar Tour 2015

2015bunsHero

Discover Glo!

Please join us for presentations and discussions to learn more about the latest developments and applications in luminescent cell-based assays.

We will be featuring presentations about the novel applications of NanoLuc® Luciferase for reporter assays and technologies for interrogating protein-protein interactions in living cells.

Network with your fellow scientists and get updated on the latest techniques for studying cell health and mechanisms of toxicity.

2014speakerIconFeatured Speaker

Featured Speaker
Dr. Thomas Machleidt
Senior Research Scientist, Advanced Technology Group, Promega Corporation, USA
Featured Talks
NanoLuc®: NextGen luciferase for analysis of protein dynamics and cell signaling

ABSTRACT


Promega’s proprietary Nanoluc™ (Nluc) luciferase is a small (19.1kDa) engineered luminescent reporter. The enzyme which is about 150-fold brighter than either firefly (Fluc) or Renilla reniformis (Rluc) luciferase and uses a novel coelenterazine analog (furimazine) to produce high intensity, glow-type luminescence. Its exceptional brightness makes NanoLuc™ an ideal candidate for the development of highly sensitive pathway reporter assays, which includes a novel dual luciferase reporter assay with improved sensitivity and dynamic range... Read more

NanoBRET™ and NanoBiT: new tools for the analysis of protein-protein interaction in living cells

ABSTRACT


All aspects of protein function and activity are governed by an intricate network of interactions between proteins and other molecular constituents. The dynamic nature of those interactions and their physiological relevance can be revealed using analytical methods that can be applied without disrupting the intracellular context. Here we present the development of two novel technology platforms, NanoBRET™ and NanoLuc® Binary Technology (NanoBiT) that enable the investigation of protein interactions with unprecedented sensitivity in living cells. Both methods rely on NanoLuc®, a small (19 kDa) luciferase enzyme engineered for structural stability and the ability to generate an intense, steady, bioluminescent signal. NanoBRET™ was conceived as novel bioluminescence resonance energy transfer (BRET) platform using NanoLuc as the donor paired with a red fluorescent acceptor... Read more

2014speakerIconGuest Speakers

United Kingdom

  • Cell-based assays to detect the mechanism of toxicity and Glomax Discover experiment: How healthy are your cells?
    Dr. Marta Rucka, Product Specialist, Promega UK
  • Novel reporter bioassays for the characterisation of therapeutic monoclonal antibodies – from ADCC/Fc effector function assays to immune checkpoint blockade
    Dr. Craig Macolm, Strategic Collaborations Manager, Promega UK

Belgium

  • Targeting the Bcl-2- IP3R interaction as an anti-cancer strategy in B-cell cancers
    Tamara Vervloessem, Laboratory of Molecular and Cellular Signaling, KU Leuven
  • Identification of GPCR ligands and signaling pathways with Glosensor™ cAMP assay
    Dr. Julien Hanson, Laboratory of Molecular Pharmacology, GIGA Signal Transduction & Laboratory of Medicinal Chemistry, Centre for interdisciplinary Research on Medicine
  • Cell-based assays to detect the mechanism of toxicity
    Dr. Zhong Yu, Product Manager, Promega Benelux
  • Luminescence kits in the development of an in vitro system to test fibrosis
    Dr. Sofia Batista Leite, Liver Cell Biology Lab, LIVR, Vrije Universiteit Brussel

Netherlands

  • Organs-on-a-Chip for early stage-screening to predict drug toxicology and efficacy in a high-throughput compatible platform
    Dr. Karlijn Wilschut, Sr Scientist Application Development, Mimetas VB, Leiden
  • Multi-tasking Paneth cells: quiescent cancer stem cells, niche factors, and colon cancer susceptibility modifiers.
    Prof. Dr. R. Fodde, Department of Experimental Pathology, Erasmus MC, Rotterdam
  • Cell-based assays to detect the mechanism of toxicity
    Dr. Zhong Yu, Product Manager, Promega Benelux
  • Luminescence kits in the development of an in vitro system to test fibrosis
    Dr. Sofia Batista Leite, Liver Cell Biology Lab, LIVR, Vrije Universiteit Brussel

Switzerland

  • Dead or alive? New cell-based assays to detect mechanism of toxicity
    Dr. Réka Nagy, Product Manager, Promega AG, Switzerland
  • GloMax® Discover! A multi-mode detection instrument for your assays
    Dr. Harald Winteler, Product Manager, Promega AG, Switzerland
  • The Bright Side of 3D Biology
    Dr. Wolfgang Moritz, InSphero AG, Switzerland
  • Dual Imaging of NanoLuc® and Firefly Luciferase by Luminescence Microscopy
    Daniel Strebinger, EPFL School of Life Sciences, Lausanne, Switzerland

Finland

  • Cell-based assays to detect the mechanism of toxicity
    Dr. Zhong Yu, Product Manager, Promega Benelux

Norway

  • Cell-based assays to detect the mechanism of toxicity
    Dr. Zhong Yu, Product Manager, Promega Benelux

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