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The Y Chromosome AZF Analysis System complies with EU Directive 98/79/EC on in vitro diagnostic medical devices. The Y Chromosome AZF Analysis System provides a multiplex PCR-based method to analyze the integrity of the human Y chromosome AZF region. The Y Chromosome AZF Analysis System is to be used as part of a diagnostic workup to characterize male infertility. This information is potentially useful for patients considering in vitro fertilization because deletions in the AZF region of the Y chromosome are passed on to male offspring produced by in vitro fertilization, resulting in infertility.
The Y Chromosome AZ...
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The Y Chromosome AZF Analysis System consists of 20 primer pairs that are homologous to previously identified and mapped sequence-tagged sites (STS). These primers will amplify nonpolymorphic short DNA segments from the AZF region of the Y chromosome, covering AZFa, AZFb, AZFc, proximal AZFc/AZFd (including DAZ, KALY and SMCY) and flanking loci for other key spermatogenesis-related genes (RBM1, DFFRY and DBY). The Y Chromosome AZF Analysis System is fully compliant with European Molecular Genetics Quality Network (EMQN) recommendations.
The primers have been combined into five Multiplex Master Mix sets (A–E) for use in multiplex PCR. This makes it possible to analyze all 20 STS by performing five concurrent PCR amplifications.
This product is compliant with EU Directive 98/79/EC on in vitro diagnostic medical devices. This product is only available in certain European countries. Contact your local Promega representative for availability.
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Store all components at –20°C. Avoid multiple freeze-thaw cycles.
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Amplification of male genomic DNA (Part# MD115A) (lanes 1, 3, 5, 7, 9), as well as a negative DNA control (lanes 2, 4, 6, 8, 10), for each of the five Multiplex Master Mixes of the Y Chromosome AZF Analysis System.
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