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Promega Corporation

VivoGlo™ Caspase 3/7 Substrate (Z-DEVD-Aminoluciferin Sodium Salt)

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VivoGlo™ Caspase-3/7 Substrate (Z-DEVD-Aminoluciferin, Sodium Salt) is a firefly luciferase prosubstrate containing the DEVD tetrapeptide sequence recognized by caspase-3 and -7. Upon activation of caspase-3 or -7, the DEVD peptide is cleaved, and the liberated aminoluciferin reacts with luciferase to generate measurable light. Cleavage has been shown in in cellulo and in vivo systems. For mice, activity of a related salt was demonstrated when 10mg of the substrate in 150μl of saline was injected intraperitoneally. Other references suggest that doses as low as 1.5mg per mouse (50mg/kg) can be used. We recommend co...

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VivoGlo™ Caspase-3/7 Substrate (Z-DEVD-Aminoluciferin, Sodium Salt)

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VivoGlo™ Caspase-3/7 Substrate (Z-DEVD-Aminoluciferin, Sodium Salt)

 Components

50mg
- P1781 $ 1,074.00 Add to cart

VivoGlo™ Caspase-3/7 Substrate (Z-DEVD-Aminoluciferin, Sodium Salt)

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VivoGlo™ Caspase-3/7 Substrate (Z-DEVD-Aminoluciferin, Sodium Salt)

 Components

5 × 50mg
- P1782 $ 3,740.00 Add to cart


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Storage Conditions

Store at –20°C.

For product intended use please see Patents & Disclaimers tab.

Use Restrictions

P1781, P1782 For Research Use Only. Not for Use in Diagnostic Procedures.

Patents - Disclaimers

P1781, P1782 The use of this product and derivatives thereof is strictly limited to that of a life sciences research reagent. All other use is strictly prohibited, including but not limited to any diagnostic, therapeutic, or commercial use. The use of this product for in vivo bioluminescent imaging may be covered by one or more patents controlled by Caliper Life Sciences, Inc. Those patents include U.S. Pat. Nos. 5,650,135, 6,217,847, 6,923,951, 6,908,605, 6,890,515, and corresponding foreign patents and pending applications. The purchase or transfer of this product is not intended, either expressly or by implication, to grant any right or license to practice under the foregoing patents. Purchasers are advised to contact Caliper Life Sciences, Inc., 68 Elm St., Hopkinton, MA 01748 for information regarding a license to practice under such patents.

P1781, P1782 This product does not convey a license to use recombinant Coleoptera luciferase under U.S. Pat. Nos. 5,583,024, 5,674,713 and 5,700,673. Promega sells licensed Coleoptera luciferase vectors, which may be used in conjunction with this product.

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