MEK Inhibitor U0126

MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). U0126 inhibits MEK1 with an IC₅₀ of 0.5μM (in vitro). It has been used in both in vivo and in vitro studies of MEK. The chemical identity of MEK Inhibitor U0126 has been confirmed by proton NMR spectroscopy.

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MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). U0126 inhibits MEK1 with an IC₅₀ of 0.5μM (in vitro). It has been used in both in vivo and in vitro studies of MEK. The chemical identity of MEK Inhibitor U0126 has been confirmed by proton NMR spectroscopy.

Features - Benefits

• Potent: U0126 inhibits Raf-activated MEK1/2 in vitro with an IC₅₀ of approximately 10–20μM.

Applications

For more information, see the Protocols & Applications Guide.

References

1. DeSilva, D.R. et al. (1998) J. Immunol. 160, 4175–81.
2. Favata, M. et al. (1998) J. Biol. Chem. 273, 18623–32.
3. Goueli, S. et al. (1998) Promega Notes 69, 6–8.
4. Tolwinski, N.S. et al. (1999) J. Biol. Chem. 274, 6168–74.
5. Li, C. et al. (1999) J. Biol. Chem. 274, 6747–53.
6. Duncia, J.V. et al. (1998) Bioorg. Med. Chem. Lett. 8, 2839–44.

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