Nuclear Receptor Pathway Tools

Vectors for Nuclear Receptor Studies

The "pBIND" vectors express fusion proteins that can induce transcription of luciferase when under control of an upstream Gal4 UAS. Each pBIND vector also contains a Renilla luciferase/neo resistance co-reporter for data normalization and transfection control.

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GloResponse™ Cell Line

This cell line contains nine repeats of GAL4 UAS, driving the transcription of the luc2P reporter gene in response to binding of a fusion protein containing the GAL4 DNA Binding Domain, making the cell line suitable for the study of nuclear receptors.

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pGL4 Luciferase Reporter Vectors

These next generation, luciferase reporter vectors offer more efficient expression of both firefly and Renilla luciferases in mammalian cells. Use the pGL4 Vector Selector to find the ideal vector for your application.

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This chapter of the Protocols and Applications Guide describes the molecular basis of cell signaling and the various assays used to study cell signaling.

This chapter of the Protocols and Applications Guide discusses the use of bioluminescent reporters to study eukarytoic gene expression and regulation including the use of single-reporter assays, dual-reporter assays, and live-cell substrates.