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Promega Corporation

SB 203580

SB 203580 [4-(4´-fluorophenyl)-2-(4´-methylsulfinylphenyl)-5-(4´-pyridyl) imidazole] is a specific, cell-permeable inhibitor of the stress- and inflammatory cytokine-activated MAP kinase homologues p38α, p38β and p38β2. SB 203580 acts as a competitive inhibitor of ATP binding. Reported IC50 values for p38 activity range from 21nM to 1μM. SB 203580 has no significant effect on the activities of ERKs, JNKs, p38γ or p38δ. The chemical identity and purity of SB 203580 is confirmed by proton NMR and elemental analysis.

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SB 203580

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Supplied as a dried material. Resuspend 1mg in 265μl of DMSO to produce a stock solution of 10mM.

Storage Conditions

Store dried material at –20°C.

For product intended use please see Patents & Disclaimers tab.

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