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Phorbol 12-myristate 13-acetate (PMA) is a specific activator of group A (α, βI, βII, γ) and group B (δ, ε, η, θ) Protein Kinase Cs (PKCs) (in the 1–100nM range). Phorbol esters, such as PMA, affect PKCs by mimicking diacylglycerol, a natural ligand and activator of PKCs. PMA is an effective skin irritant and potent tumor promoter in mice. A common alternative name for PMA is 12-O-tetradecanoylphorbol 13-acetate (TPA). The chemical identity and purity of PMA are confirmed by proton NMR.
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This product is available through the Promega Helix onsite stocking program in a –20°C Helix Freezer. The program offers numerous convenient solutions to meet your lab's needs. Helix Freezers are available in two sizes: 5.7 cubic ft. or 9.7 cubic ft.
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Supplied as a dried material. Resuspend 5mg in 1.62ml of DMSO to produce a stock solution of 5mM.
Store dried material at –20°C.
For product intended use please see Patents & Disclaimers tab.
V1171 For Research Use Only. Not for Use in Diagnostic Procedures.
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