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See All Kinase Enzyme Systems
Recombinant full-length human CK2α1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. CK2α1 is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lympho-proliferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2).
ADP-Glo™ Kinase Assay...
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ADP-Glo™ Kinase Assay is a luminescent kinase assay that measures ADP formed from a kinase reaction; ADP is converted into ATP, which is a substrate in a reaction catalyzed by Ultra-Glo™ Luciferase that produces light. The luminescent signal positively correlates with ADP amount and kinase activity. The assay is well suited for measuring the effects chemical compounds have on the activity of a broad range of purified kinases, making it ideal for both primary screening as well as kinase selectivity profiling. The ADP-Glo™ Kinase Assay can be used to monitor the activity of virtually any ADP-generating enzyme (e.g., kinase or ATPase) using up to 1mM ATP.
Kinase Enzyme System contains:
CK2α1 NCBI Database Entry.
Human Kinase Enzyme Systems and Applications.
Kinase Enzyme System manufactured by SignalChem.
Bulk quantities available upon request.
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CK2α1 Kinase Enzyme System
ADP-Glo™ Kinase Assay
Upon receipt, centrifuge the kinase and dispense it into smaller quantities. Store the kinase at –70°C and the rest of the components at –20°C.
For product intended use please see Patents & Disclaimers tab.
V4482, V6287, V4483 For Research Use Only. Not for Use in Diagnostic Procedures.
V4483 U.S. Pat. Nos. 7,083,911, 7,452,663 and 7,732,128 and other patents.
V4483 U.S. Pat. No. 7,700,310 and other patents and patents pending.
V4483 U.S. Pat. Nos. 7,741,067, 8,361,739 and 8,603,767 and other patents and patents pending.
V4483 U.S. Pat. Nos. 6,602,677, 7,241,584, 8,030,017 and 8,822,170 and other patents and patents pending.
V4483 U.S. Pat. No. 8,183,007 and other patents and patents pending.
V4483 Licensed from Lonza Nottingham Ltd. under U.S. Pat. Nos. 6,599,711 and 6,911,319 and other pending and issued patents.
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