Press Releases
Promega pmirGLO Brings New Capability for Study of microRNA Activity
MADISON, WISCONSIN (February 26, 2009)
Promega Corporation announces the availability of the new
pmirGLO Dual-Luciferase miRNA Target Expression Vector.
pmirGLO supports both breadth and depth in the microRNA
study. Researchers have both ability to measure a wide
dynamic range of miRNA activity in a vast number of cell
types and the option to create a stable cell line from one
genetic construct for further research. More specifically,
pmirGLO uses optimized firefly luciferase gene as the
readout for activity, while also offering a Renilla
luciferase/neomycin resistance gene for data normalization.
The pmirGLO vector allows a luciferase reporter gene assay
to measure the function of endogenous or exogenous micro
RNAs (miRNA). This vector also enables functional studies of
sequence variations found in 3'-untranslated regions of
genes often related to miRNA binding sites or other
modulators of transcript stability. These elements are
cloned into the pmirGLO vector to create a transcriptional
fusion to firefly luciferase, allowing quantitative results
with a simple and sensitive assay. This vector is the most
recent addition to a collection of nearly 50 luciferase
reporter vectors offered by Promega.
For more information, visit
www.promega.com.
About Promega
Promega Corporation is a leader in
providing innovative solutions and technical support to the life
sciences industry. The company's 2,000 products enable
scientists worldwide to advance their knowledge in genomics,
proteomics, cellular analysis, molecular diagnostics and human
identification. Founded in 1978, the company is headquartered in
Madison, WI, USA with branches in 14 countries and over 50
global distributors. For more information about Promega, visit
www.promega.com
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