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Researchers can efficiently screen entire genetic pathways in living cells with new tools developed by SwitchGear Genomics. The product offering, which includes the first ready-to-screen libraries for high-throughput regulatory pathway research, consists of thousands of human promoters, UTRs and other regulatory elements encompassing many different disease-related pathways.
"Our philosophy at SwitchGear Genomics is that conclusions can be made with much higher confidence by integrating the data from multiple independent genome-scale experiments," explains Shelley Force Aldred, President of SwitchGear Genomics. "These integrated data sets will explain a transcriptional regulatory network in much greater detail than if the data sets were analyzed independently of one another."
The new tools contain Promega luciferase reporter technology. Specifically, this new offering leverages all the strengths of luciferase reporters in ease, sensitivity to provide insights into cellular signaling events following xenobiotic treatment.
"The Promega luciferase reporters, specifically the luc2P construct, offer the best characteristics in a bioluminescent reporter assay. It really delivers the strongest sensitivity, dynamic range, turnover rate and compatibility with high-throughput platforms," says Force Aldred.
All of the regulatory elements in the libraries are cloned in a vector containing the luc2P gene, a destabilized luciferase that contains a Pro-Glu-Ser-Thr (PEST) peptide sequence for faster response time and decreased time to maximum induction.
Nathan Trinklein, PhD, CEO of SwitchGear Genomics will present the new technology at:
Drug Discovery & Development of Innovative Therapeutics World Congress
Boston, MA
Exhibit Conference Hall
August 8, 2007
About SwitchGear Genomics
SwitchGear Genomics is based in Menlo Park, California, and was founded by scientists from Stanford University in 2005. The goal of SwitchGear Genomics is to provide custom research services and experimental tools to aid researchers in large-scale studies of transcriptional regulation. For more information about SwitchGear Genomics, visit www.switchgeargenomics.com.
About Promega
Promega Corporation is a leader in providing innovative solutions and technical support to the life sciences industry. The company's 1,450 products enable scientists worldwide to advance their knowledge in genomics, proteomics, cellular analysis, molecular diagnostics and human identification. Founded in 1978, the company is headquartered in Madison, WI, USA with branches in twelve countries and 54 global distributors. Annual sales exceed $190 million.
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