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High-Throughput Compound Profiling Using Tecan Instrumentation
Tracy Worzella, M.S., and Brad Larson, B.A.
Promega Corporation
Combining high-throughput, homogeneous screening assays and integrated
automated instrumentation allows researchers to efficiently profile
compounds that may be potential drugs. To assess if the compounds of
interest are worth pursuing, multiple assays are required to examine
cell responses (e.g., apoptosis) and effects on nontarget biochemical
systems such as cytochrome P450 and kinases. Knowing how the drug
affects its target and becoming aware of any potential cytotoxicity and
other off-target effects are essential in the drug discovery
decision-making process.
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