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Correlation of Caspase Activity and Chemo-Response in Epithelial Ovarian Cancer Cell Lines
Ayesha B.
Alvero, M.D., and Gil Mor, M.D., Ph.D.
Department of Obstetrics and
Gynecology, Yale University School of Medicine
The immediate assessment of
response to therapy is most beneficial to ovarian cancer patients. This
study shows the correlation of drug-induced caspase activation determined
by Western blot analysis and by the Caspase-Glo™ Assay. Our initial
research demonstrates that the Caspase-Glo™ Assay provides a simple,
fast and sensitive alternative for the evaluation of in vitro response to
cytotoxic agents. The clinical correlation of caspase activity and
response to treatment is under investigation.
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